Comparative Study of Swept-source Optical Coherence Tomography Angiography Metrics Between Eyes With Adult Onset Vitelliform Dystrophy, Age-related Macular Degeneration, and Healthy Controls.

IF 1.1 4区医学 Q4 OPHTHALMOLOGY

Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-04-01 Epub Date: 2026-03-16 DOI:10.3928/23258160-20260122-02

Ken Whang, Itika Garg, Iris Deitch Harel, Raviv Katz, Ying Cui, Rebecca Zeng, Margaret Duich, Hannah E Wescott, Thomas Koch, Augustine Bannerman, Grace Baldwin, Archana Nigalye, Ines Lains, Dean Eliott, Nimesh A Patel, Leo A Kim, Demetrios G Vavvas, Joan W Miller, Deeba Hussain, John B Miller

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引用次数: 0

Abstract

Background and objective: The aim of this study was to investigate swept-source OCT angiography (SSOCTA) metrics in adult-onset foveovitelliform dystrophy (AOFVD), intermediate age-related macular degeneration (iAMD), and healthy control eyes.

Patients and methods: A cross-sectional study analyzing SS-OCTA foveal avascular zone (FAZ), vessel skeletonized density (VSD), and vessel density (VD) using the ARI network was conducted. A mixed-effects multiple regression model adjusting for age was used for statistical analyses.

Results: The cohort included 204 eyes of 125 patients (control, n = 63; iAMD, n = 93; AOFVD, n = 48). Compared to iAMD, AOFVD eyes had significantly reduced VD, VSD, and FAZ circularity on 3 × 3-mm and 6 × 6-mm angiograms, and significantly increased FAZ area and FAZ perimeter on 6 × 6-mm angiograms. There was no difference on 12 × 12-mm angiograms. Compared to controls, AOFVD eyes had significantly reduced FAZ circularity on 3 × 3-mm angiograms.

Conclusion: SS-OCTA metrics may help in distinguishing AOFVD from iAMD.

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成人黄斑营养不良、年龄相关性黄斑变性和健康对照的扫描源光学相干断层血管造影指标比较研究

背景和目的：本研究的目的是探讨成人发病的中央卵泡状营养不良（AOFVD）、中度年龄相关性黄斑变性（iAMD）和健康对照眼的扫描源OCT血管造影（SS-OCTA）指标。患者和方法：采用ARI网络进行SS-OCTA中央凹无血管区（FAZ）、血管骨架化密度（VSD）和血管密度（VD）的横断面研究。采用年龄调整后的混合效应多元回归模型进行统计分析。结果：共纳入125例患者204只眼（对照组63只，iAMD 93只，AOFVD 48只）。与iAMD相比，AOFVD眼在3 × 3-mm和6 × 6-mm血管造影上的VD、VSD和FAZ圆度明显降低，6 × 6-mm血管造影上的FAZ面积和FAZ周长明显增加。12 × 12mm血管造影无差异。与对照组相比，AOFVD的眼睛在3 × 3-mm血管造影上的FAZ圆度明显降低。结论：SS-OCTA指标有助于区分AOFVD和iAMD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.