Celiac Disease and HLADQ2/DQ8 Genotypes in Severe Acute Malnutrition: A Hospital-Based Study.

IF 1.5 4区医学 Q2 PEDIATRICS

Indian pediatrics Pub Date : 2026-08-01 Epub Date: 2026-03-17 DOI:10.1007/s13312-026-00297-5

Swetketu Singh, Ankur Singh, Vinod Kumar, Ved Prakash Singh, Akhtar Ali, Amrita Ghosh Kar, Abhishek Abhinay, Rajniti Prasad

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引用次数: 0

Abstract

Objectives: To determine the proportion of celiac disease (CD) among children with severe acute malnutrition (SAM) and to evaluate the distribution and association of HLA-DQ2/DQ8 genotypes in affected children.

Methods: Children aged 6-59 months diagnosed with SAM were assessed for inclusion. Those with secondary causes of SAM like underlying chronic illnesses like congenital heart disease, renal disease, or immunodeficiency were excluded. All participants were tested for tissue transglutaminase (tTG) immunoglobulin A serology, endoscopic biopsy of duodenum and HLA DQ2/DQ8 genotyping. tTG IgA serology positive and histopathology compatible (Modified Marsh grade ≥ II) cases were grouped as group A (SAM with CD). Rest of the cases were grouped as group B (SAM without CD).

Results: Out of 140 children with SAM, 20 with secondary causes of malnutrition were excluded. 40 out of 140 participants (28.57%) were tTG IgA positive with duodenal biopsy confirmatory of CD (group A). HLA-DQ2/DQ8 positivity was observed in 95% in group A and 57% of group B (P < 0.001). The most frequent genotype was HLA-DQ2.5 (67.5% in group A, 35% in group B; OR = 3.86, 95% CI 1.72-8.63).

Conclusion: A substantial proportion of children with SAM have undiagnosed CD with HLA-DQ2.5 genotype being the most common genotype.

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严重急性营养不良中乳糜泻和HLADQ2/DQ8基因型：一项基于医院的研究

目的：了解严重急性营养不良（SAM）患儿中乳糜泻（CD）的比例，评价HLA-DQ2/DQ8基因型在患儿中的分布及其相关性。方法：对诊断为SAM的6-59个月儿童进行纳入评估。那些有次要原因的人，如潜在的慢性疾病，如先天性心脏病、肾脏疾病或免疫缺陷，被排除在外。所有参与者进行了组织转谷氨酰胺酶（tTG）免疫球蛋白A血清学检测、十二指肠内镜活检和HLA DQ2/DQ8基因分型检测。tTG IgA血清学阳性且组织病理学符合（改良Marsh分级≥II）的病例分为A组（SAM合并CD）。其余病例为B组（无CD）。结果：140例急性营养不良患儿中，排除了20例继发性营养不良患儿。140名参与者中有40名（28.57%）tTG IgA阳性，十二指肠活检证实为CD （A组）。HLA-DQ2/DQ8阳性在A组中占95%，在B组中占57% (P结论：相当比例的SAM儿童患有未确诊的CD，其中HLA-DQ2.5基因型是最常见的基因型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.