Comorbid Schizophrenia and Psychotic Symptoms in Patients With Bipolar Disorder: A Meta-Analysis of the Global Literature

IF 4.5 2区医学 Q1 CLINICAL NEUROLOGY

Bipolar Disorders Pub Date : 2026-03-18 DOI:10.1111/bdi.70093

Wen Shao, Kangning Shao, Richard P. Bentall

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引用次数: 0

Abstract

Background

The boundary between bipolar disorder and schizophrenia has long been blurred by the shared psychopathology, genetic risk, and social factors. This study aims to examine the prevalence of psychosis and psychotic symptoms in bipolar patients.

Method

Key words ‘bipolar’, ‘psychosis’, ‘schizophrenia’, and the variants were searched in titles and abstracts using Medline, Psych INFO and Web of Science and forward and backward citation searches were conducted; effects were computed using single proportion analysis with double arcsine transformation.

Results

The final analysis comprised 285 studies. The comorbidity of schizophrenia diagnoses in bipolar patients was low (8%). However, more broadly defined mood incongruent psychosis was quite prevalent (47%). Similarly, psychotic symptoms were common in bipolar patients, specifically those with a type I diagnosis or manic episode; delusions were more common than hallucinations and thought disorders.

Conclusions

Significant overlap in phenomenology and psychopathology was observed between bipolar disorder and schizophrenia in this review. Future research should focus on comparing patients with similar symptoms and exploring the shared processes that contribute to these symptoms.

Abstract Image

查看原文本刊更多论文

双相情感障碍患者的共病性精神分裂症和精神病症状：全球文献荟萃分析

背景：长期以来，双相情感障碍和精神分裂症之间的界限被共同的精神病理、遗传风险和社会因素所模糊。本研究旨在探讨双相情感障碍患者精神病和精神病症状的患病率。方法：使用Medline、Psych INFO和Web of Science检索标题和摘要中的关键词“bipolar”、“psychosis”、“schizophrenia”及其变体，并进行前后引文检索；效果计算采用单比例分析和双反正弦变换。结果：最终分析包括285项研究。双相情感障碍患者诊断出精神分裂症的合并症较低（8%）。然而，更广泛定义的情绪不一致精神病相当普遍（47%）。同样，精神病症状在双相患者中也很常见，特别是那些I型诊断或躁狂发作的患者；妄想比幻觉和思维障碍更常见。结论：本综述观察到双相情感障碍和精神分裂症在现象学和精神病理学上有显著的重叠。未来的研究应侧重于比较具有相似症状的患者，并探索导致这些症状的共同过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bipolar Disorders 医学-精神病学

CiteScore

8.20

自引率

7.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Bipolar Disorders is an international journal that publishes all research of relevance for the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses. It intends to provide a single international outlet for new research in this area and covers research in the following areas: biochemistry physiology neuropsychopharmacology neuroanatomy neuropathology genetics brain imaging epidemiology phenomenology clinical aspects and therapeutics of bipolar disorders Bipolar Disorders also contains papers that form the development of new therapeutic strategies for these disorders as well as papers on the topics of schizoaffective disorders, and depressive disorders as these can be cyclic disorders with areas of overlap with bipolar disorders. The journal will consider for publication submissions within the domain of: Perspectives, Research Articles, Correspondence, Clinical Corner, and Reflections. Within these there are a number of types of articles: invited editorials, debates, review articles, original articles, commentaries, letters to the editors, clinical conundrums, clinical curiosities, clinical care, and musings.