Structure-guided identification of dipeptides modulating PPARα-associated lipid metabolism.

IF 1.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-05-20 DOI:10.1093/bbb/zbag037

Arata Banno, Rana Yu, Nanami Nishino, Mako Yamamoto, Asahi Takeuchi, Natsuki Oda, Akio Ebihara, Satoshi Nagaoka

引用次数: 0

Abstract

The structural basis for dipeptides modulating PPARα remains unclear. AlphaFold2 identified Ile-His as a candidate predicted to interact with a novel alternative binding site. In HepG2 cells, Ile-His and Phe-Ala reduced cholesterol accumulation, whereas Ala-Pro had no effect. These findings support the utility of structure-based prediction as a hypothesis-generating approach for identifying dipeptides associated with PPARα-related modulation of lipid metabolism.

查看原文本刊更多论文

结构引导鉴定调节ppar α相关脂质代谢的二肽。

二肽调节PPARα的结构基础尚不清楚。AlphaFold2将Ile-His鉴定为预测与一个新的替代结合位点相互作用的候选基因。在HepG2细胞中，Ile-His和phea - ala减少了胆固醇的积累，而Ala-Pro没有作用。这些发现支持基于结构的预测作为一种假设生成方法的效用，用于识别与ppar α相关的脂质代谢调节相关的二肽。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).