Addressing the Lp(a) hypothesis: will lowering Lp(a) decrease the risk of cardiovascular events?

IF 50.2 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Nature Reviews Cardiology Pub Date : 2026-03-17 DOI:10.1038/s41569-026-01278-8

Marlys L. Koschinsky, Michael B. Boffa

引用次数: 0

Abstract

Elevated plasma concentrations of lipoprotein(a) (Lp(a)) are an important risk factor for several cardiovascular diseases. However, to date, elevated Lp(a) levels have not been directly targeted by clinicians because Lp(a) levels are almost entirely genetically determined and are comparatively resistant to standard lipid-lowering therapies. This unmet medical need might soon be addressed with the advent of potent Lp(a)-lowering therapies.

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解决Lp(a)假设：降低Lp(a)会降低心血管事件的风险吗？

血浆脂蛋白(a)浓度升高（Lp(a)）是几种心血管疾病的重要危险因素。然而，到目前为止，临床医生还没有直接针对Lp(a)水平升高进行治疗，因为Lp(a)水平几乎完全是由基因决定的，并且对标准降脂疗法具有相对的抗性。随着有效的Lp(a)降低疗法的出现，这种未被满足的医疗需求可能很快得到解决。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Cardiology 医学-心血管系统

CiteScore

53.10

自引率

0.60%

发文量

143

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cardiology aims to be the go-to source for reviews and commentaries in the scientific and clinical communities it serves. Focused on providing authoritative and accessible articles enriched with clear figures and tables, the journal strives to offer unparalleled service to authors, referees, and readers, maximizing the usefulness and impact of each publication. It covers a broad range of content types, including Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives, catering to practising cardiologists and cardiovascular research scientists. Authored by renowned clinicians, academics, and researchers, the content targets readers in the biological and medical sciences, ensuring accessibility across various disciplines. In-depth Reviews offer up-to-date information, while Consensus Statements provide evidence-based recommendations. Perspectives and News & Views present topical discussions and opinions, and the Research Highlights section filters primary research from cardiovascular and general medical journals. As part of the Nature Reviews portfolio, Nature Reviews Cardiology maintains high standards and a wide reach.