Role of BARX1 in Development and Disease

IF 2.8 4区生物学 Q2 DEVELOPMENTAL BIOLOGY

genesis Pub Date : 2026-03-16 DOI:10.1002/dvg.70045

Yiwen Ma, Xiaorui Li, Liping Xiao, Ying Wang, Wei Zheng, Guilian Liang, Tao Sun

引用次数: 0

Abstract

Homeobox genes encode diverse proteins, including proteins with highly conserved DNA-binding domains, and are essential for organismal growth, cell differentiation, organ development, and diverse physiological processes associated with diseases. BARX1 encodes a transcription factor containing the BarH1-like homeodomain. This gene plays a significant role in the development of various tissues and is closely associated with the pathogenesis and progression of numerous diseases. In this review, we provide a comprehensive overview of the functional networks and mechanisms of action of the BARX1 gene across different tissue developmental processes and disease contexts.

查看原文本刊更多论文

BARX1在发育和疾病中的作用。

同源盒基因编码多种蛋白质，包括具有高度保守的dna结合结构域的蛋白质，是生物体生长、细胞分化、器官发育和与疾病相关的多种生理过程所必需的。BARX1编码一个包含barh1样同源结构域的转录因子。该基因在各种组织的发育中起着重要作用，与许多疾病的发病和进展密切相关。在这篇综述中，我们提供了BARX1基因在不同组织发育过程和疾病背景下的功能网络和作用机制的全面概述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

genesis 生物-发育生物学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： As of January 2000, Developmental Genetics was renamed and relaunched as genesis: The Journal of Genetics and Development, with a new scope and Editorial Board. The journal focuses on work that addresses the genetics of development and the fundamental mechanisms of embryological processes in animals and plants. With increased awareness of the interplay between genetics and evolutionary change, particularly during developmental processes, we encourage submission of manuscripts from all ecological niches. The expanded numbers of genomes for which sequencing is being completed will facilitate genetic and genomic examination of developmental issues, even if the model system does not fit the “classical genetic” mold. Therefore, we encourage submission of manuscripts from all species. Other areas of particular interest include: 1) the roles of epigenetics, microRNAs and environment on developmental processes; 2) genome-wide studies; 3) novel imaging techniques for the study of gene expression and cellular function; 4) comparative genetics and genomics and 5) animal models of human genetic and developmental disorders. genesis presents reviews, full research articles, short research letters, and state-of-the-art technology reports that promote an understanding of the function of genes and the roles they play in complex developmental processes.