Meng Cao, Mengli Xu, Yuewen Su, Jun Xu, Zhenghua Ji, Qinghui Chen, Yuqin Li, Weifang Zhou
{"title":"Functional study of peripheral blood CD8 + T cells in Epstein-Barr virus-associated infectious mononucleosis.","authors":"Meng Cao, Mengli Xu, Yuewen Su, Jun Xu, Zhenghua Ji, Qinghui Chen, Yuqin Li, Weifang Zhou","doi":"10.1186/s13052-026-02229-2","DOIUrl":null,"url":null,"abstract":"<p><p>BACKGROUND: This study aimed to explore the function and clinical significance of peripheral blood CD8 + T cells in EBV-associated infectious mononucleosis (IM). METHODS: From June 2022 to May 2024, blood samples of 48 IM children and 24 healthy controls were collected. ELISA detected IFN-γ, IL-10, TGF-β1 levels, and RT-PCR measured perforin and granzyme B mRNA levels. RESULTS: results showed higher white blood cell, lymphocyte counts, etc. in the case group. Also, more CD3+, CD3 + CD8+ and NK cells, lower CD4+/CD8 + ratio were found in cases. IFN-γ, IL-10, perforin, granzyme B were higher, while TGF-β1 was lower in cases. Some negative and positive correlations were found among cytokines and cell counts. CONCLUSION: CD8 + T cells and their related cytokines IFN-γ, IL-10, TGF-β1, perforin and granzyme B are involved in the immune process of infectious mononucleosis related to EBV. CLINICAL TRIAL NUMBER: Not applicable. </p>","PeriodicalId":14511,"journal":{"name":"Italian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13104447/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Italian Journal of Pediatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13052-026-02229-2","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
Abstract
BACKGROUND: This study aimed to explore the function and clinical significance of peripheral blood CD8 + T cells in EBV-associated infectious mononucleosis (IM). METHODS: From June 2022 to May 2024, blood samples of 48 IM children and 24 healthy controls were collected. ELISA detected IFN-γ, IL-10, TGF-β1 levels, and RT-PCR measured perforin and granzyme B mRNA levels. RESULTS: results showed higher white blood cell, lymphocyte counts, etc. in the case group. Also, more CD3+, CD3 + CD8+ and NK cells, lower CD4+/CD8 + ratio were found in cases. IFN-γ, IL-10, perforin, granzyme B were higher, while TGF-β1 was lower in cases. Some negative and positive correlations were found among cytokines and cell counts. CONCLUSION: CD8 + T cells and their related cytokines IFN-γ, IL-10, TGF-β1, perforin and granzyme B are involved in the immune process of infectious mononucleosis related to EBV. CLINICAL TRIAL NUMBER: Not applicable.
期刊介绍：
Italian Journal of Pediatrics is an open access peer-reviewed journal that includes all aspects of pediatric medicine. The journal also covers health service and public health research that addresses primary care issues.
The journal provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field.
Italian Journal of Pediatrics, which commenced in 1975 as Rivista Italiana di Pediatria, provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
