POBS Relieves Antigen-Induced Experimental Sjögren's Disease by Regulating B Lymphocyte Subsets via CXCL13/CXCR5 Signaling Pathway

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

IUBMB Life Pub Date : 2026-03-16 DOI:10.1002/iub.70095

Xiaosheng Lei, Na Li, Qiaolin Zhang, Meng Yang, Yuhao Xuan, Qi Liu, Xiaoyun Chen, Wei Wei, Ruilin Li, Huaxun Wu

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引用次数: 0

Abstract

Sjögren's Disease (SjD) is an autoimmune disorder characterized by lymphocyte infiltration into exocrine glands, leading to dry eyes and mouth. Its pathogenesis involves B cell hyperactivity and type I interferon activation. CXCL13 promotes B cell migration and ectopic germinal center formation in target tissues. This study investigated whether paeoniflorin-6′-O-benzene sulfonate (POBS) alleviates Experimental Sjögren's Disease (ESjD) by modulating B cell subsets via the CXCL13/CXCR5 pathway. Altered B cell subsets were observed in SjD patient blood and labial glands, suggesting memory B cell migration. In SG-protein immunised ESjD mice, POBS reduced lymphocyte infiltration in submandibular glands, suppressed splenic B cell activation, and modulated peripheral B cell subpopulations. POBS also downregulated CXCL13 and CXCR5 expression. These results demonstrate that POBS attenuates gland damage and immune infiltration by regulating B cells via CXCL13/CXCR5, indicating its therapeutic potential for SjD.

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POBS通过CXCL13/CXCR5信号通路调节B淋巴细胞亚群缓解抗原诱导的实验性Sjögren病

Sjögren's Disease （SjD）是一种自身免疫性疾病，其特征是淋巴细胞浸润到外分泌腺，导致眼睛和口干。其发病机制涉及B细胞过度活跃和I型干扰素激活。CXCL13在靶组织中促进B细胞迁移和异位生发中心形成。本研究探讨芍药苷-6′-邻苯磺酸盐（POBS）是否通过CXCL13/CXCR5通路调节B细胞亚群，从而缓解实验性Sjögren病（ESjD）。在SjD患者血液和唇腺中观察到改变的B细胞亚群，提示记忆性B细胞迁移。在sg蛋白免疫的ESjD小鼠中，POBS减少了颌下腺淋巴细胞的浸润，抑制了脾B细胞的活化，并调节了外周血B细胞亚群。POBS还下调了CXCL13和CXCR5的表达。这些结果表明，POBS通过CXCL13/CXCR5调节B细胞，减轻了腺体损伤和免疫浸润，提示其治疗SjD的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IUBMB Life 生物-生化与分子生物学

CiteScore

10.60

自引率

0.00%

发文量

109

审稿时长

4-8 weeks

期刊介绍： IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine.