Neuropsychiatric and behavioural correlates of sundowning in Alzheimer's disease.

IF 2.3 4区医学 Q2 PSYCHIATRY

International Journal of Psychiatry in Clinical Practice Pub Date : 2026-09-01 Epub Date: 2026-03-16 DOI:10.1080/13651501.2026.2642681

Antonina Luca, Maria Luca, Raffaele Ferri, Giuseppe Lanza, Alessandro Serretti

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引用次数: 0

Abstract

Objectives: The aims of this study were to estimate the frequency of 'sundown syndrome' (SS) in a large sample of patients with Alzheimer's disease (AD) and to assess its associated socio-demographic and clinical variables.

Methods: Three hundred and sixty-one AD patients (age 78.4 ± 8.3 years) collected within the National Institute of Mental Health Genetics Initiative were included. A subsample was autopsy-confirmed. SS was identified within a caregiver-structured interview. Sociodemographic, clinical and neuropsychiatric features of sundowners and non-sundowners were compared by logistic regression.

Results: One hundred eighty-five patients (51.2%) were sundowners. SS was positively associated with several neuropsychiatric symptoms (i.e., hallucinations, suspiciousness, wandering and aggression; all p-values < 0.01), and negatively associated with Mini-Mental State Examination and voluptuary habits (all p values < 0.05). Subsample analysis carried out in the autopsy group confirmed the findings.

Conclusions: SS is common in AD and is associated with several neuropsychiatric features and voluptuary habits. The identification of SS predictive factors may allow preventive and targeted therapeutic interventions.

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阿尔茨海默病日落的神经精神和行为相关。

目的：本研究的目的是在大量阿尔茨海默病（AD）患者中估计“日落综合征”（SS）的频率，并评估其相关的社会人口统计学和临床变量。方法：从国家心理健康遗传学倡议研究所收集的361例AD患者（年龄78.4±8.3岁）。尸检证实了一个子样本。SS是在护理人员结构的访谈中确定的。采用logistic回归方法比较日暮者和非日暮者的社会人口学、临床和神经精神特征。结果：85例（51.2%）患者为昏厥患者。SS与幻觉、多疑、徘徊、攻击等神经精神症状呈正相关（p值均< 0.01），与小精神状态检查、好色习惯呈负相关（p值均< 0.05）。在尸检组进行的亚样本分析证实了这一发现。结论：SS在AD中很常见，并与一些神经精神特征和好色习惯有关。识别SS的预测因素可以进行预防和有针对性的治疗干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Psychiatry in Clinical Practice 医学-精神病学

CiteScore

6.00

自引率

3.30%

发文量

审稿时长

>12 weeks

期刊介绍： International Journal of Psychiatry in Clinical Practice provides an international forum for communication among health professionals with clinical, academic and research interests in psychiatry. The journal gives particular emphasis to papers that integrate the findings of academic research into realities of clinical practice. Focus on the practical aspects of managing and treating patients. Essential reading for the busy psychiatrist, trainee and interested physician. Includes original research papers, comprehensive review articles and short communications. Key words: Psychiatry, Neuropsychopharmacology, Mental health, Neuropsychiatry, Clinical Neurophysiology, Psychophysiology, Psychotherapy, Addiction, Schizophrenia, Depression, Bipolar Disorders and Anxiety.