Comparison of Serum Zn, Cu, Mg, Mn, Cr, and Fe Levels in Iraqi COVID-19 Patients and their Association with Infection Severity.

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Indian Journal of Clinical Biochemistry Pub Date : 2026-04-01 Epub Date: 2024-08-06 DOI:10.1007/s12291-024-01254-4

Falah S Al-Fartusie, Safaa I Kader, Sara Jassim Mohammed, Fahim Muhsin Mahmood, Anwar A Algaber, Majeed N Farhan

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引用次数: 0

Abstract

An ideal level of vital trace elements (TE) is crucial for the immune system to protect organs from infections. TE, in particular, zinc (Zn), copper (Cu), magnesium (Mg), manganese (Mn), chromium (Cr), and iron (Fe), affect an individual's sensitivity to the exposure and progression of viral diseases, such as COVID-19. Therefore, this study evaluated the level of these TE during hospitalization in an isolation center and investigated their association with the severity of COVID-19. This study included 118 individuals, 63 male and 55 female aged between 20 and 60 years. Seventy-eight COVID-19 patients and 40 healthy individuals were included in this study. Infected individuals were classified into moderate and severe based on the severity of their symptoms. The levels of Zn, Mg, Mn, Cr, and Fe were significantly decreased in moderate and severe groups compared to the controls (p < 0.0001), respectively. Conversely, levels of Cu were found significantly increasing compared to individuals in the control's groups (p < 0.0001). Among the total number of infected cases, the levels of Zn, Cu, Mn, Cr, and Fe did not significantly increase with increasing severity (from moderate to severe). The findings indicated that TE levels were not altered in a severity-dependent manner, showing that TE affect the individual's vulnerability to COVID-19, not its progression.

Supplementary information: The online version contains supplementary material available at 10.1007/s12291-024-01254-4.

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伊拉克新冠肺炎患者血清Zn、Cu、Mg、Mn、Cr和Fe水平的比较及其与感染严重程度的关系

理想水平的重要微量元素（TE）对免疫系统保护器官免受感染至关重要。TE，特别是锌（Zn）、铜（Cu）、镁（Mg）、锰（Mn）、铬（Cr）和铁（Fe），会影响个体对暴露和病毒性疾病（如COVID-19）进展的敏感性。因此，本研究评估了隔离中心住院期间这些TE的水平，并调查了它们与COVID-19严重程度的关系。这项研究包括118个人，其中男性63人，女性55人，年龄在20至60岁之间。本研究纳入78名COVID-19患者和40名健康个体。根据症状的严重程度，将感染者分为中度和重度。与对照组相比，中度和重度组的Zn、Mg、Mn、Cr和Fe水平显著降低（p p）。补充信息：在线版本包含补充资料，可在10.1007/s12291-024-01254-4。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Clinical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

4.50

自引率

4.80%

发文量

期刊介绍： The primary mission of the journal is to promote improvement in the health and well-being of community through the development and practice of clinical biochemistry and dissemination of knowledge and recent advances in this discipline among professionals, diagnostics industry, government and non-government organizations. Indian Journal of Clinical Biochemistry (IJCB) publishes peer reviewed articles that contribute to the existing knowledge in all fields of Clinical biochemistry, either experimental or theoretical, particularly deal with the applications of biochemistry, molecular biology, genetics, biotechnology, and immunology to the diagnosis, treatment, monitoring and prevention of human diseases. The articles published also include those covering the analytical and molecular diagnostic techniques, instrumentation, data processing, quality assurance and accreditation aspects of the clinical investigations in which chemistry has played a major role, or laboratory animal studies with biochemical and clinical relevance.