Sequential Development of Albino Rabbit Iris During Fetal and Postnatal Life: Histological, Ultrastructural, and Immunohistochemical Investigations.

IF 3 4区工程技术 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Microscopy and Microanalysis Pub Date : 2026-03-03 DOI:10.1093/mam/ozag015

Nagwa Ibrahim, Sara M M Eldesoky

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Abstract

The iris has several unique structures that are determined by its embryonic origin. Therefore, this research aimed to demonstrate the morphogenesis of the albino rabbit iris. The development of the rabbit iris began at mid-gestation and was completed postnatally. Consequently, we used 36 embryos and 12 neonatal rabbits. The iris originated from the tip of the optic cup. The epithelium of the iris began to differentiate on day 15 of pregnancy, forming a single layer of epithelial cells. The constrictor muscle began its differentiation on day 27 of pregnancy in the area around the pupil, while the dilator muscle differentiated on day 30 as a protrusion from the anterior epithelial cells. The stroma of the iris differentiated from the periocular mesenchyme into fibroblasts, telocytes, dendritic cells, and macrophages. The tyrosinase enzymes expressed in the albino rabbit's iris were inactive and at low levels, with melanocytes lacking melanin pigment. Vimentin immunohistochemistry expression was observed in all layers of the iris. Desmin was expressed only in the constrictor muscle and stroma. Explaining the developmental process of the albino's iris is vital for advancing our knowledge of this tissue.

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白化兔虹膜在胎儿和出生后的顺序发育：组织学、超微结构和免疫组织化学研究。

虹膜有几个独特的结构，这是由它的胚胎起源决定的。因此，本研究旨在证实白化兔虹膜的形态发生。兔虹膜的发育始于妊娠中期，并在出生后完成。因此，我们使用了36个胚胎和12只新生兔。虹膜起源于视杯的尖端。妊娠第15天虹膜上皮开始分化，形成单层上皮细胞。妊娠第27天收缩肌在瞳孔周围区域开始分化，而扩张肌在妊娠第30天分化为前上皮细胞的突起。虹膜基质由眼周间充质分化为成纤维细胞、远端细胞、树突状细胞和巨噬细胞。白化兔虹膜酪氨酸酶表达失活，表达水平低，黑色素细胞缺乏黑色素。虹膜各层均可见血凝蛋白免疫组化表达。Desmin仅在收缩肌和间质中表达。解释白化病虹膜的发育过程对于提高我们对这一组织的认识至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microscopy and Microanalysis 工程技术-材料科学：综合

CiteScore

1.10

自引率

10.70%

发文量

1391

审稿时长

6 months

期刊介绍： Microscopy and Microanalysis publishes original research papers in the fields of microscopy, imaging, and compositional analysis. This distinguished international forum is intended for microscopists in both biology and materials science. The journal provides significant articles that describe new and existing techniques and instrumentation, as well as the applications of these to the imaging and analysis of microstructure. Microscopy and Microanalysis also includes review articles, letters to the editor, and book reviews.