[Daily online adaptive irradiation of bladder tumors with individualized safety margin creation].

Magyar onkologia Pub Date : 2026-03-12 Epub Date: 2025-03-03

Gabriella Dóra Pulugor, Ádám Gáldi, Levente Varga, Kliton Jorgo, László Gesztesi, András Herein, Domonkos Szegedi, Zsuzsa S Kocsis, Tibor Major, Csaba Polgár, Zoltán Takácsi-Nagy, Péter Ágoston

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引用次数: 0

Abstract

Aim: Daily online adaptive radiation therapy (OART) allows the creation of individualized safety margins based on daily optimized treatment planning, taking into account daily anatomy variations. The goal of our work was to compare the protocols and safety margins of a non-adapted, image- guided radiation therapy (IGRT), a published Danish and the National Institute of Oncology of Hungary (NIO) protocol in the first eight bladder cancer patients treated with OART.

Methods: Three cone beam CTs (CBCT) were taken during the first three fractions: after patient positioning, after adaptation, and at the end of treatment. Bladder contours, extensions and margins were established on all CT images (n=512). Intraadaptational, intrafractional and interfractional changes were examined.

Results: Regarding PTV, a mean reduction of 12.2% could be achieved using the Danish, and 34.1% using the NIO protocol compared to IGRT. Healthy tissue irradiated by the prescribed dose could be reduced. The target volume miss is decreased as well.

Conclusions: PTV could be reduced and optimized, increasing healthy tissue protection using OART.

本刊更多论文

【每日在线自适应照射膀胱肿瘤及个体化安全裕度创建】。

目的：每日在线适应性放射治疗（OART）允许在每日优化治疗计划的基础上创建个性化的安全边际，同时考虑到日常解剖变化。我们工作的目的是比较前8名接受OART治疗的膀胱癌患者的非适应性图像引导放射治疗（IGRT）方案和安全边际，这是丹麦和匈牙利国家肿瘤研究所（NIO）发表的方案。方法：在患者体位后、适应后和治疗结束前三个阶段分别进行三次锥形束ct （CBCT）。在所有CT图像上建立膀胱轮廓、延伸和边缘（n=512）。研究了适应内、适应内和分数间的变化。结果：在PTV方面，与IGRT相比，使用丹麦方案可平均降低12.2%，使用NIO方案可平均降低34.1%。按规定剂量照射的健康组织可以减少。目标体积丢失也减少了。结论：OART可降低和优化PTV，增强对健康组织的保护。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Magyar onkologia

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