Alex Demarsh, Pedro Nascimento de Lima, Cassidy Nelson, Javier Rojas Aguilera, Nathan Duarte, Sella Nevo, Henry H Willis
{"title":"Strategies to Improve Detection of Novel Pandemic Pathogens: Cost Versus Detection Performance for Promising Pathogen-Agnostic Detection Workflows.","authors":"Alex Demarsh, Pedro Nascimento de Lima, Cassidy Nelson, Javier Rojas Aguilera, Nathan Duarte, Sella Nevo, Henry H Willis","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>This RAND analysis compares three pathogen-agnostic biosurveillance strategies-syndromic, wearable, and environmental-using modeling to assess cost versus detection performance. Environmental sampling detected outbreaks fastest, followed by wearable sensors, although both lost advantage with highly transmissible or symptomatic diseases. Limited pilot deployments could refine real-world costs and validate early-warning performance.</p>","PeriodicalId":74637,"journal":{"name":"Rand health quarterly","volume":"13 2","pages":"9"},"PeriodicalIF":0.0000,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978668/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rand health quarterly","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/3/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
This RAND analysis compares three pathogen-agnostic biosurveillance strategies-syndromic, wearable, and environmental-using modeling to assess cost versus detection performance. Environmental sampling detected outbreaks fastest, followed by wearable sensors, although both lost advantage with highly transmissible or symptomatic diseases. Limited pilot deployments could refine real-world costs and validate early-warning performance.