Next-generation proximity labeling: redefining protein interactomes.

IF 21.2 1区生物学 Q1 PLANT SCIENCES

Trends in Plant Science Pub Date : 2026-08-01 Epub Date: 2026-03-11 DOI:10.1016/j.tplants.2026.02.011

Xinlin Liang, Yongliang Zhang, Wolfram Weckwerth, Yanmei Chen

引用次数: 0

Abstract

Protein-protein interactions (PPIs) are fundamental to cellular function and metabolic regulation. Mapping these complex molecular networks is essential for understanding signaling pathways, yet it remains challenging due to their transient nature. We discuss how next-generation proximity labeling is evolving from bulk methods toward precise, dynamic PPI mapping, providing actionable biological insights.

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下一代接近标记：重新定义蛋白质相互作用组。

蛋白质-蛋白质相互作用（PPIs）是细胞功能和代谢调节的基础。绘制这些复杂的分子网络对于理解信号通路至关重要，但由于它们的瞬态性质，仍然具有挑战性。我们讨论了下一代接近标记如何从批量方法发展到精确、动态的PPI制图，提供可操作的生物学见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Plant Science 生物-植物科学

CiteScore

31.30

自引率

2.00%

发文量

196

审稿时长

6-12 weeks

期刊介绍： Trends in Plant Science is the primary monthly review journal in plant science, encompassing a wide range from molecular biology to ecology. It offers concise and accessible reviews and opinions on fundamental plant science topics, providing quick insights into current thinking and developments in plant biology. Geared towards researchers, students, and teachers, the articles are authoritative, authored by both established leaders in the field and emerging talents.