{"title":"Design and Characterization of Doxepin In-situ Nasal Gel Using Pectin as a Bio-compatible Matrix.","authors":"Antesh Kumar Jha, Shiv Kumar Srivastava, Mahesh Prasad","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The goal of the current study is to formulate a Doxepin hydrochloride ion triggered trans-nasal gel. The developed formulations were evaluated for gel strength, gelation time, viscosity, mucoadhesion strength, ex-vivo drug permeability drug content, and stability. According to the findings, mucoadhesive strength and viscosity increased as pectin and hydroxypropyl methylcellulose (HPMC) K4M concentrations increased, whereas gelation time and the percentage of drug recovery decreased. With 3.5% pectin and 1.5% HPMC, the improved formulation C2F2 demonstrated the greatest drug release of 97.96% via sheep nasal mucosa. The stability study over a period of three months showed no change in viscosity, pH and drug content. The discovered ion-triggered intra nasal formulations shows enhanced locomotor activity and mobility in mice, when used to treat depression.</p>","PeriodicalId":14381,"journal":{"name":"International journal of pharmaceutical compounding","volume":"30 1","pages":"42-56"},"PeriodicalIF":0.0000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of pharmaceutical compounding","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
The goal of the current study is to formulate a Doxepin hydrochloride ion triggered trans-nasal gel. The developed formulations were evaluated for gel strength, gelation time, viscosity, mucoadhesion strength, ex-vivo drug permeability drug content, and stability. According to the findings, mucoadhesive strength and viscosity increased as pectin and hydroxypropyl methylcellulose (HPMC) K4M concentrations increased, whereas gelation time and the percentage of drug recovery decreased. With 3.5% pectin and 1.5% HPMC, the improved formulation C2F2 demonstrated the greatest drug release of 97.96% via sheep nasal mucosa. The stability study over a period of three months showed no change in viscosity, pH and drug content. The discovered ion-triggered intra nasal formulations shows enhanced locomotor activity and mobility in mice, when used to treat depression.
期刊介绍：
The International Journal of Pharmaceutical Compounding (IJPC) is a bi-monthly, scientific and professional journal emphasizing quality pharmaceutical compounding. IJPC is the only publication that covers pharmaceutical compounding topics relevant and necessary to empower pharmacists to meet the needs of today"s patients. No other publication features hands-on, how-to compounding techniques or the information that contemporary pharmacists need to provide individualized care.
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