The Burden of Epilepsy in Thailand: Estimating Societal Costs and Quality of Life.

IF 2.3 4区医学 Q2 CLINICAL NEUROLOGY

Behavioural Neurology Pub Date : 2026-01-01 DOI:10.1155/bn/2885542

Prapassara Sirikarn, Surachai Phimha, Luxzup Wattanasukchai, Sineenard Mungmanitmongkol, Somsak Tiamkao

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Abstract

Background: Epilepsy imposes both economic and quality-of-life (QOL) burdens. Therefore, this study is aimed at evaluating the costs of illness and QOL in patients with epilepsy (PWE) and their caregivers and to examine the differences in costs and QOL across patient characteristics.

Methods: This prevalence-based cost-of-illness study was conducted from a societal perspective. Data were collected from patients who attended the Epilepsy Clinic at Srinagarind Hospital, Khon Kaen University, between April and August 2023. QOLs were assessed using the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) for PWE and the EuroQoL-5D-5L (EQ-5D-5L) for caregivers. A generalized linear model was used to assess the differences in costs and QOL across patient and caregiver characteristics.

Results: A total of 214 subjects were enrolled in this study, comprising 129 PWE and 85 caregivers. The mean total cost of illness per outpatient visit was 452.27 PPP-USD, with 58.0% attributed to direct medical costs, 24.4% to direct nonmedical costs, and 17.6% to indirect costs. Direct medical costs differed significantly based on employment status (p value = 0.031) and seizure control (p value = 0.018). Direct nonmedical costs showed differences by residential distance (p value < 0.001). Indirect costs also showed differences by age (p value = 0.019) and residential distance (p value = 0.002). The lifetime productivity loss from unemployment reached 14638.37 PPP-USD per patient. The mean overall QOLIE-31 score was 74.04 points, and the mean EQ-5D-5L index was 0.90. There were differences in QOL based on age and seizure control in PWE, as well as age and unemployment status in caregivers.

Conclusion: Direct medical costs were the largest component of total costs. Cost differences were found across age, employment status, residential distance, and seizure control. QOL varied by age and seizure control in PWE and by age and unemployment status in caregivers.

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泰国癫痫的负担：估计社会成本和生活质量。

背景：癫痫会给经济和生活质量（QOL）带来负担。因此，本研究旨在评估癫痫患者及其护理人员的疾病成本和生活质量，并检查不同患者特征的成本和生活质量差异。方法：从社会角度进行基于患病率的疾病成本研究。数据收集自2023年4月至8月期间在孔敬大学斯利那加林医院癫痫诊所就诊的患者。使用PWE的癫痫生活质量量表-31 （QOLIE-31）和护理人员的EuroQoL-5D-5L （EQ-5D-5L）评估生活质量。采用广义线性模型来评估患者和护理人员特征在成本和生活质量方面的差异。结果：本研究共纳入214名受试者，其中PWE 129名，护理人员85名。每次门诊就诊的平均总疾病成本为452.27 PPP-USD，其中58.0%为直接医疗成本，24.4%为直接非医疗成本，17.6%为间接成本。直接医疗费用因就业状况（p值= 0.031）和癫痫控制（p值= 0.018）而有显著差异。直接非医疗费用因居住距离不同而有差异（p值< 0.001）。间接成本也存在年龄（p值= 0.019）和居住距离（p值= 0.002）的差异。失业导致的终身生产力损失达到14638.37 PPP-USD /患者。QOLIE-31总分平均为74.04分，EQ-5D-5L指数平均为0.90分。PWE患者的生活质量与年龄、癫痫发作控制、照顾者的年龄和失业状况有关。结论：直接医疗费用占总费用的比重最大。不同年龄、就业状况、居住距离和癫痫控制之间存在成本差异。PWE患者的生活质量因年龄和癫痫控制而异，护理者的生活质量因年龄和失业状况而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Neurology 医学-临床神经学

CiteScore

5.40

自引率

3.60%

发文量

审稿时长

>12 weeks

期刊介绍： Behavioural Neurology is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on various diseases and syndromes in behavioural neurology. The aim of the journal is to provide a platform for researchers and clinicians working in various fields of neurology including cognitive neuroscience, neuropsychology and neuropsychiatry. Topics of interest include: ADHD Aphasia Autism Alzheimer’s Disease Behavioural Disorders Dementia Epilepsy Multiple Sclerosis Parkinson’s Disease Psychosis Stroke Traumatic brain injury.