Clinicopathological and Molecular Characterization of Pediatric Breast Fibroepithelial Lesions: A Cohort Study.

IF 0.8 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2026-03-01 Epub Date: 2026-03-11 DOI:10.1080/15513815.2026.2640505

Jie Zhang, Weimao Kong, Longnv Bao, Guilin Yang, Kongzheng Yang, Tingling Zhang, Xingzhu Pan, Jigang Wang

{"title":"Clinicopathological and Molecular Characterization of Pediatric Breast Fibroepithelial Lesions: A Cohort Study.","authors":"Jie Zhang, Weimao Kong, Longnv Bao, Guilin Yang, Kongzheng Yang, Tingling Zhang, Xingzhu Pan, Jigang Wang","doi":"10.1080/15513815.2026.2640505","DOIUrl":null,"url":null,"abstract":"Objective: The aim of this study is to characterize the clinicopathological and molecular features of pediatric breast fibroepithelial lesions (FELs) and evaluate the diagnostic and clinical relevance of distinguishing fibroadenomas (FAs) from phyllodes tumors (PTs).Methods: We retrospectively analyzed 138 pediatric breast FELs. Pathologic evaluation, immunohistochemical staining, and Sanger sequencing of MED12 exon 2 and the TERT promoter were performed.Results: Of the 138 cases, 133 were diagnosed as FAs (96.4%) and five as benign PTs (3.6%). CD34, Ki-67, and p16 expression were correlated with mitotic activity. CD34 also associated with atypia, and Ki-67 with stromal overgrowth. Larger sized tumors (≥4 cm) had mutant MED12 (30/45 cases). No TERT promoter mutations were detected. During follow-up (range 17-153 months), no true recurrences occurred; though, 13 patients developed new lesions in other quadrants or contralateral breast.Conclusions: Pediatric FELs likely represent a diagnostic continuum. In this cohort, the distinction between FA and benign PT did not impact clinical outcome, suggesting limited prognostic significance.","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"108-121"},"PeriodicalIF":0.8000,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fetal and Pediatric Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15513815.2026.2640505","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/3/11 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: The aim of this study is to characterize the clinicopathological and molecular features of pediatric breast fibroepithelial lesions (FELs) and evaluate the diagnostic and clinical relevance of distinguishing fibroadenomas (FAs) from phyllodes tumors (PTs).

Methods: We retrospectively analyzed 138 pediatric breast FELs. Pathologic evaluation, immunohistochemical staining, and Sanger sequencing of MED12 exon 2 and the TERT promoter were performed.

Results: Of the 138 cases, 133 were diagnosed as FAs (96.4%) and five as benign PTs (3.6%). CD34, Ki-67, and p16 expression were correlated with mitotic activity. CD34 also associated with atypia, and Ki-67 with stromal overgrowth. Larger sized tumors (≥4 cm) had mutant MED12 (30/45 cases). No TERT promoter mutations were detected. During follow-up (range 17-153 months), no true recurrences occurred; though, 13 patients developed new lesions in other quadrants or contralateral breast.

Conclusions: Pediatric FELs likely represent a diagnostic continuum. In this cohort, the distinction between FA and benign PT did not impact clinical outcome, suggesting limited prognostic significance.

查看原文本刊更多论文

儿童乳腺纤维上皮病变的临床病理和分子特征：一项队列研究。

目的：本研究旨在探讨儿童乳腺纤维上皮病变（FELs）的临床病理和分子特征，并评估区分纤维腺瘤（FAs）和叶状瘤（PTs）的诊断和临床意义。方法：回顾性分析138例小儿乳腺肿块。对MED12外显子2和TERT启动子进行病理评估、免疫组织化学染色和Sanger测序。结果：138例中，FAs确诊133例（96.4%），良性PTs确诊5例（3.6%）。CD34、Ki-67和p16的表达与有丝分裂活性相关。CD34也与异型性有关，Ki-67与间质过度生长有关。较大的肿瘤（≥4cm）有MED12突变体（30/45例）。未检测到TERT启动子突变。在随访期间（17-153个月），未发生真正的复发；然而，13例患者在其他象限或对侧乳房出现新的病变。结论：儿童fel可能代表一个诊断连续体。在这个队列中，FA和良性PT的区别不影响临床结果，提示预后意义有限。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.