Lipid metabolism in pancreatic cancer treatment.

IF 3.2 Q3 ONCOLOGY

World journal of clinical oncology Pub Date : 2026-02-24 DOI:10.5306/wjco.v17.i2.114959

Chi Zhang, Hao Wang, Yan-Hui Yang

引用次数: 0

Abstract

Pancreatic cancer (PC) represents one of the most formidable challenges in oncology, necessitating continuous innovation in therapeutic strategies. Owing to its pivotal role in PC progression, lipid metabolism, which is characterized by dysregulated cholesterol biosynthesis, altered fatty acid profiles, and lipid-driven immunosuppression, has received increasing attention. These metabolic aberrations fuel tumour growth, chemoresistance, and metastasis while impairing immune surveillance. By targeting lipid pathways, emerging therapies hold promise for disrupting cancer cell survival and redefining PC treatment paradigms.

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胰腺癌治疗中的脂质代谢。

胰腺癌（PC）是肿瘤学中最艰巨的挑战之一，需要不断创新治疗策略。由于其在PC进展中的关键作用，以胆固醇生物合成失调、脂肪酸谱改变和脂质驱动的免疫抑制为特征的脂质代谢受到越来越多的关注。这些代谢异常促进肿瘤生长、耐药和转移，同时损害免疫监测。通过靶向脂质途径，新兴疗法有望破坏癌细胞存活并重新定义PC治疗范式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World journal of clinical oncology ONCOLOGY-

自引率

0.00%

发文量

585

期刊介绍： The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.