Josephat M Chinawa, Okechukwu S Ani, Odutola I Odetunde
{"title":"Left ventricular mass in newborn with perinatal asphxia: Assessment of allometric relations and impact of birth weight.","authors":"Josephat M Chinawa, Okechukwu S Ani, Odutola I Odetunde","doi":"10.12998/wjcc.v14.i6.117269","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Utero-placental insufficiency seen in perinatal asphyxia may adversely affect left ventricular (LV) geometry.</p><p><strong>Aim: </strong>To document the LV mass values in perinatal asphyxia and to elicit associated factors.</p><p><strong>Methods: </strong>This was a cross-sectional study conducted in a tertiary health facility among newborns with perinatal asphyxia. Echocardiography was used to compare the LV mass of 84 new-borns with perinatal asphyxia with the LV mass of 48 new-borns without perinatal asphyxia matched for age. The data was analysed using SPSS version 25 (IBM, United States).</p><p><strong>Results: </strong>The mean LV mass (7.9 ± 2.3 g) of perinatal asphyxia is lower than control (10.1 ± 0.7 g) <i>P</i> = 0.001. New-borns with severe perinatal asphyxia had the lowest mean LV mass (7.1 ± 1.5), while the moderate group had the highest (8.8 ± 2.5), with the Analysis of Variance (ANOVA) result of <i>F</i> = 1.26 and <i>P</i> = 0.289. The mean LV mass was highest on day 1 (8.1 ± 2.5) and slightly lower on days 2 and 3 (both 7.7 ± 1.9 and 7.7 ± 2.0, respectively). Though ANOVA result (<i>F</i> = 2.47, <i>P</i> = 0.7282) indicates no significant relationship between the age of the newborn and LV mass, a weak positive correlation was observed between LV mass and gestational age which is statistically significant (<i>r</i> = 0.269 <i>P</i> = 0.028). A moderate positive correlation between the LV mass and birth weight of newborn was observed. This is statistically significant (<i>r</i> = 0.610, <i>P</i> = 0.001). There was weak negative correlation (<i>r</i> = -0.10, <i>P</i> = 0.752), between LV mass and age of the newborn without perinatal asphyxia but a moderate positive correlation (<i>r</i> = 0.69, <i>P</i> = 0.015) was observed, between LV mass and weight in non-asphyxiated newborn.</p><p><strong>Conclusion: </strong>This study showed that the LV mass in perinatal asphyxia was significantly lower than those without asphyxia. There was a direct correlation between LV mass and birth weight of neonates with perinatal asphyxia. Early detection of the cardiac disease, appropriate management and sustained reduction of birth asphyxia, and improved intra-partum quality of care are key.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"14 6","pages":"117269"},"PeriodicalIF":1.0000,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968534/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Clinical Cases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12998/wjcc.v14.i6.117269","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Utero-placental insufficiency seen in perinatal asphyxia may adversely affect left ventricular (LV) geometry.
Aim: To document the LV mass values in perinatal asphyxia and to elicit associated factors.
Methods: This was a cross-sectional study conducted in a tertiary health facility among newborns with perinatal asphyxia. Echocardiography was used to compare the LV mass of 84 new-borns with perinatal asphyxia with the LV mass of 48 new-borns without perinatal asphyxia matched for age. The data was analysed using SPSS version 25 (IBM, United States).
Results: The mean LV mass (7.9 ± 2.3 g) of perinatal asphyxia is lower than control (10.1 ± 0.7 g) P = 0.001. New-borns with severe perinatal asphyxia had the lowest mean LV mass (7.1 ± 1.5), while the moderate group had the highest (8.8 ± 2.5), with the Analysis of Variance (ANOVA) result of F = 1.26 and P = 0.289. The mean LV mass was highest on day 1 (8.1 ± 2.5) and slightly lower on days 2 and 3 (both 7.7 ± 1.9 and 7.7 ± 2.0, respectively). Though ANOVA result (F = 2.47, P = 0.7282) indicates no significant relationship between the age of the newborn and LV mass, a weak positive correlation was observed between LV mass and gestational age which is statistically significant (r = 0.269 P = 0.028). A moderate positive correlation between the LV mass and birth weight of newborn was observed. This is statistically significant (r = 0.610, P = 0.001). There was weak negative correlation (r = -0.10, P = 0.752), between LV mass and age of the newborn without perinatal asphyxia but a moderate positive correlation (r = 0.69, P = 0.015) was observed, between LV mass and weight in non-asphyxiated newborn.
Conclusion: This study showed that the LV mass in perinatal asphyxia was significantly lower than those without asphyxia. There was a direct correlation between LV mass and birth weight of neonates with perinatal asphyxia. Early detection of the cardiac disease, appropriate management and sustained reduction of birth asphyxia, and improved intra-partum quality of care are key.
期刊介绍：
The World Journal of Clinical Cases (WJCC) is a high-quality, peer reviewed, open-access journal. The primary task of WJCC is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of clinical cases. In order to promote productive academic communication, the peer review process for the WJCC is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCC are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in clinical cases.
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