Surgical Management of Esthesioneuroblastoma at a Single Tertiary Care Center.

IF 0.9 4区医学 Q3 Medicine

Journal of Neurological Surgery Part B: Skull Base Pub Date : 2025-04-30 eCollection Date: 2026-04-01 DOI:10.1055/a-2587-6160

Evan J Patel, Christine Glastonbury, Annemieke van Zante, Sue S Yom, Michael McDermott, Philip Theodosopoulos, Manish Aghi, Ezequiel Goldschmidt, Ivan El-Sayed

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引用次数: 0

Abstract

Objectives: To analyze management strategies and outcomes for patients with esthesioneuroblastoma (ENB) undergoing surgical resection at a single institution.

Methods: Retrospective review from 1971 to 2022 from a single, high-volume tertiary academic center of all patients with ENB.

Results: A total of 60 patients received their primary treatment for ENB at our institution. The average age at diagnosis was 52 years (range 13-91), and most were male (66.7%) with Kadish C (61.7%) stage at presentation. Most patients were treated with an open approach (68.3%) compared with a purely endoscopic approach (31.7%). Median follow-up was 96.9 months (mean 118.8 months, interquartile range 28.4-183.8 months). There was one patient with local recurrence in the endoscopic cohort (5.3%) compared with 22.0% (9 patients) among those who underwent an open resection ( p = 0.21). The 5-year survival was 87.2% (95% CI, 71.9-100.0%) in the endoscopic cohort compared with 80.2% (95% CI, 68.8-93.5%) in the open group ( p = 0.60). The rate of death or recurrence within 5 years of treatment was comparable between open and endoscopic (32.5% vs. 15.0%, p = 0.26). Among Kadish C patients treated in the endoscopic era (after 2006), 5-year survival was 76.2% (95% CI, 52.1-100.0%) in the endoscopic cohort and 64.8% (95% CI, 39.3-100.0%) in the open group ( p = 0.70).

Conclusion: The surgical approach for ENB resection is dictated by tumor extension. Endoscopic resection offers a less invasive approach with comparable postoperative outcomes in appropriately selected patients.

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在单一三级护理中心的神经母细胞瘤的外科治疗。

目的：分析在单一机构接受手术切除的感觉神经母细胞瘤（ENB）患者的治疗策略和结果。方法：回顾性分析1971年至2022年来自单一、高容量三级学术中心的所有ENB患者。结果：共有60例患者在我院接受了ENB的初步治疗。平均诊断年龄为52岁（范围13-91岁），多数为男性（66.7%），首发时为卡迪什C期（61.7%）。大多数患者采用开放入路（68.3%），而纯内窥镜入路（31.7%）。中位随访时间为96.9个月（平均118.8个月，四分位数间距28.4 ~ 183.8个月）。内镜组有1例局部复发（5.3%），而开放切除术组有22.0%（9例）局部复发（p = 0.21）。内镜组的5年生存率为87.2% (95% CI, 71.9-100.0%)，而开放组的5年生存率为80.2% (95% CI, 68.8-93.5%) （p = 0.60）。5年内的死亡率或复发率在开放和内窥镜治疗之间是相当的（32.5%比15.0%,p = 0.26）。在内镜时代（2006年以后）治疗的Kadish C患者中，内镜组的5年生存率为76.2% (95% CI, 52.1-100.0%)，开放组的5年生存率为64.8% (95% CI, 39.3-100.0%) （p = 0.70）。结论：ENB切除的手术入路取决于肿瘤的扩大。内镜切除提供了一种侵入性较小的方法，在适当选择的患者中具有相当的术后结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neurological Surgery Part B: Skull Base CLINICAL NEUROLOGY-SURGERY

CiteScore

2.20

自引率

0.00%

发文量

516

期刊介绍： The Journal of Neurological Surgery Part B: Skull Base (JNLS B) is a major publication from the world''s leading publisher in neurosurgery. JNLS B currently serves as the official organ of several national and international neurosurgery and skull base societies. JNLS B is a peer-reviewed journal publishing original research, review articles, and technical notes covering all aspects of neurological surgery. The focus of JNLS B includes microsurgery as well as the latest minimally invasive techniques, such as stereotactic-guided surgery, endoscopy, and endovascular procedures. JNLS B is devoted to the techniques and procedures of skull base surgery.