Accelerometer-derived "weekend warrior" physical activity pattern and risk of age-related eye diseases: a prospective cohort study.

IF 5.2 1区医学 Q1 OPHTHALMOLOGY

Eye and Vision Pub Date : 2026-03-10 DOI:10.1186/s40662-026-00480-6

Yuze Mi, Jiahui Zong, Shangdong Wang, Qinnan Zhu, Shaokai Lin, Xinni Zheng, Yanggang Hong, Jiawei Zhou, Liang Ye

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引用次数: 0

Abstract

Background: International guidelines recommend at least 150 min of weekly moderate-to-vigorous physical activity (MVPA), but whether concentrated versus distributed activity patterns differ in their associations with age-related eye diseases remains unclear.

Methods: This prospective cohort study included 86,271 UK Biobank participants free of age-related eye diseases at baseline. Physical activity was assessed using wrist-mounted triaxial accelerometers (Axivity AX3) over seven consecutive days. Two MVPA thresholds were examined: ≥ 150 min/week (primary) and ≥ 300 min/week (secondary). Participants were categorized as: inactive (below threshold), weekend warriors (WW; meeting threshold with ≥ 50% MVPA concentrated within 1-2 days), or regularly active (meeting threshold without WW criteria). Cox proportional hazards regression models were used to assess associations over a median follow-up of 7.9 years.

Results: At the ≥ 150 min/week threshold, both WW (hazard ratio [HR] = 0.89, 95% confidence interval [CI]: 0.84-0.94, P < 0.001) and regularly active patterns (HR = 0.93, 95% CI: 0.87-0.99, P = 0.028) were associated with a reduced risk of cataract compared to inactivity. The WW pattern was also associated with a reduced risk of diabetic retinopathy (DR, HR = 0.74, 95% CI: 0.55-0.99, P = 0.043) and age-related macular degeneration (AMD, HR = 0.85, 95% CI: 0.75-0.97, P = 0.016). Direct comparisons between the WW and regularly active patterns showed no significant differences for these conditions (all P > 0.05), except for a nominal difference in glaucoma (P = 0.036). At the ≥ 300 min/week threshold, only the WW pattern remained significantly associated with reduced risk of cataract (HR = 0.91, 95% CI: 0.86-0.97, P = 0.002) and glaucoma (HR = 0.86, 95% CI: 0.75-0.97, P = 0.019).

Conclusion: Both the WW and regularly active patterns demonstrate protective associations with age-related eye diseases compared to inactivity, with no statistically significant differences between the two active groups for most outcomes. These findings suggest that the WW approach is a viable and flexible alternative for individuals who find it difficult to maintain daily physical activity.

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加速度计衍生的“周末战士”身体活动模式与年龄相关眼病风险：一项前瞻性队列研究

背景：国际指南建议每周至少进行150分钟的中高强度身体活动（MVPA），但集中式和分散式活动模式与年龄相关性眼病的关联是否不同尚不清楚。方法：这项前瞻性队列研究包括86,271名基线时无年龄相关性眼病的英国生物银行参与者。使用腕戴式三轴加速度计（Axivity AX3）连续7天评估身体活动。检查两个MVPA阈值：≥150分钟/周（主要）和≥300分钟/周（次要）。参与者被分类为：不活动（低于阈值），周末战士（WW；满足阈值，1-2天内MVPA浓度≥50%），或定期活动（满足阈值，无WW标准）。Cox比例风险回归模型用于评估中位随访7.9年的相关性。结果：≥150分钟/周阈值时，除了青光眼的名义差异（P = 0.036）外，两个WW（风险比[HR] = 0.89, 95%可信区间[CI]: 0.84-0.94, P 0.05）。≥300分钟/周阈值时，只有WW模式与白内障（HR = 0.91, 95% CI: 0.86-0.97, P = 0.002）和青光眼（HR = 0.86, 95% CI: 0.75-0.97, P = 0.019）的风险降低显著相关。结论：与不运动相比，WW和定期运动模式都显示出与年龄相关眼病的保护关联，在大多数结果上，两个运动组之间没有统计学上的显著差异。这些发现表明，对于那些难以维持日常身体活动的人来说，WW方法是一种可行且灵活的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye and Vision OPHTHALMOLOGY-

CiteScore

8.60

自引率

2.40%

发文量

审稿时长

15 weeks

期刊介绍： Eye and Vision is an open access, peer-reviewed journal for ophthalmologists and visual science specialists. It welcomes research articles, reviews, methodologies, commentaries, case reports, perspectives and short reports encompassing all aspects of eye and vision. Topics of interest include but are not limited to: current developments of theoretical, experimental and clinical investigations in ophthalmology, optometry and vision science which focus on novel and high-impact findings on central issues pertaining to biology, pathophysiology and etiology of eye diseases as well as advances in diagnostic techniques, surgical treatment, instrument updates, the latest drug findings, results of clinical trials and research findings. It aims to provide ophthalmologists and visual science specialists with the latest developments in theoretical, experimental and clinical investigations in eye and vision.