Characterization and evaluation of properties of a tissue conditioner containing co-polymerizable quaternary ammonium-based antimicrobial monomers.

IF 1.8 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Dental materials journal Pub Date : 2026-05-25 Epub Date: 2026-03-10 DOI:10.4012/dmj.2025-257

Sowmya Rao, Vidya Pai, Ashwini Prabhu, Kishore Ginjupalli, Nandish Bantarahalli Thopegowda, Ranajit DAS, Runki Saran, Vijeesh Vijayan, Rijesh Malayathodi, Vikesh Kumar, Manojna K M

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引用次数: 0

Abstract

In this study, a commercially available tissue conditioner (TC; Soft-Liner, GC, Tokyo, Japan) was modified by incorporating quaternary ammonium salts (QAS): dimethyl-hexadecyl-methacryloxyethyl-ammonium iodide (DHMAI) and 2-dimethyl-2-dodecyl-1-methacryloxyethyl ammonium iodide (DDMAI) based on their minimum inhibitory and bactericidal concentrations (MIC and MBC). The control group consisted of TC materials without monomers. The modified TC was characterized by Fourier transform infrared spectroscopy, antimicrobial activity (microbial adherence) assessed against Streptococcus mutans (S. mutans), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans), and cytotoxicity (MTT assay) on L-929 fibroblasts. Additionally, mechanical and physical properties were assessed. Our results suggest that modified TC has effectively reduced microbial adhesion, exhibited good cytocompatibility and no significant changes were observed in the mechanical properties compared to control samples.

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含有可共聚合季铵盐抗菌单体的组织调理剂的表征和性能评价。

本研究采用季铵盐（QAS）：二甲基-十六烷基-甲基丙烯氧乙基碘化铵（DHMAI）和2-二甲基-2-十二烷基-1-甲基丙烯氧乙基碘化铵（DDMAI），根据其最小抑菌浓度（MIC和MBC）对市售组织调节剂（TC; Soft-Liner， GC, Tokyo, Japan）进行改性。对照组为不含单体的TC材料。利用傅里叶变换红外光谱对改性后的TC进行了表征，对变形链球菌（S. mutans）、金黄色葡萄球菌（S. aureus）和白色念珠菌（C. albicans）的抗菌活性（微生物粘附性）进行了评估，并对L-929成纤维细胞进行了细胞毒性（MTT试验）。此外，还对其机械和物理性能进行了评估。我们的研究结果表明，改性的TC有效地降低了微生物粘附，具有良好的细胞相容性，与对照样品相比，机械性能没有明显变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dental materials journal 医学-材料科学：生物材料

CiteScore

4.60

自引率

4.00%

发文量

102

审稿时长

3 months

期刊介绍： Dental Materials Journal is a peer review journal published by the Japanese Society for Dental Materials and Devises aiming to introduce the progress of the basic and applied sciences in dental materials and biomaterials. The dental materials-related clinical science and instrumental technologies are also within the scope of this journal. The materials dealt include synthetic polymers, ceramics, metals and tissue-derived biomaterials. Forefront dental materials and biomaterials used in developing filed, such as tissue engineering, bioengineering and artificial intelligence, are positively considered for the review as well. Recent acceptance rate of the submitted manuscript in the journal is around 30%.