Is physical fitness associated with brain structure and function in Parkinson's disease?

IF 2.8 3区医学 Q2 NEUROIMAGING

Brain Imaging and Behavior Pub Date : 2026-03-11 DOI:10.1007/s11682-026-01098-x

Adrian R Corfitsen, Mikkel K E Nygaard, Simon F Eskildsen, Ulrik Dalgas, Martin Langeskov-Christensen

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Abstract

We investigated associations between physical fitness (cardiorespiratory fitness (VO2max), peak muscle power (Pmax)) and brain structure (magnetic resonance imaging (MRI) measures) and function (cognition) in people with Parkinson’s disease (pwPD). Simple and multiple linear regression analyses were performed using quantitative susceptibility mapping, diffusion imaging, and volumetric MRI data from 105 pwPD. Simple regression analyses showed significant positive associations between VO2max/Pmax and whole-brain volume (r2 = 0.11/0.12), the Symbol Digit Modalities Test (SDMT) (r2 = 0.18/0.21), the Montreal Cognitive Assessment (MoCA) (r2 = 0.12/0.12) as well as volume of white and gray matter structures (total white/gray matter, putamen, caudate, pallidus, thalamus). When adjusted for age and sex, associations between VO2max and cognition (SDMT, MoCA) and between Pmax and total white matter volume, pallidus volume, and cognition (SDMT) remained significant. Physical fitness was weakly to moderately associated with cognitive function and some MRI markers of neurodegeneration in pwPD. These exploratory findings further support the potential neuroprotective effect of exercise in pwPD and may aid in selecting outcomes in future trials evaluating the neuroprotective effects of exercise.

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帕金森病患者的身体健康是否与大脑结构和功能有关？

我们研究了帕金森病（pwPD）患者的身体健康（心肺适能（VO2max）、肌肉峰值功率（Pmax））、大脑结构（磁共振成像（MRI）测量）和功能（认知）之间的关系。使用定量敏感性图、扩散成像和105例pwPD的体积MRI数据进行简单和多元线性回归分析。简单回归分析显示，VO2max/Pmax与全脑体积（r2 = 0.11/0.12）、符号数字模态测试（SDMT）（r2 = 0.18/0.21）、蒙特利尔认知评估（MoCA）（r2 = 0.12/0.12）以及白质和灰质结构（总白质/灰质、壳核、尾状核、苍白体、丘脑）体积呈正相关。在对年龄和性别进行调整后，VO2max与认知（SDMT、MoCA）以及Pmax与总白质体积、苍白质体积和认知（SDMT）之间的关联仍然显著。身体健康与pwPD患者的认知功能和一些神经退行性变的MRI标志物呈弱至中度相关。这些探索性发现进一步支持了运动对pwPD的潜在神经保护作用，并可能有助于在未来评估运动神经保护作用的试验中选择结果。

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来源期刊

Brain Imaging and Behavior 医学-神经成像

CiteScore

7.20

自引率

0.00%

发文量

154

审稿时长

3 months

期刊介绍： Brain Imaging and Behavior is a bi-monthly, peer-reviewed journal, that publishes clinically relevant research using neuroimaging approaches to enhance our understanding of disorders of higher brain function. The journal is targeted at clinicians and researchers in fields concerned with human brain-behavior relationships, such as neuropsychology, psychiatry, neurology, neurosurgery, rehabilitation, and cognitive neuroscience.