Unveiling heterogeneity in individual thresholds: validation using urinary prostaglandin D₂ metabolite in food allergy reactions.

IF 2.1 4区医学 Q3 ALLERGY

Allergologia et immunopathologia Pub Date : 2026-03-01 eCollection Date: 2026-01-01 DOI:10.15586/aei.v54i2.1525

Hisako Ogasawara, Yusuke Inuzuka, Kotaro Umezawa, Nanae Nagata, Mami Shimada, Sayaka Hamaguchi, Tatsuki Fukuie, Tatsuo Shimosawa, Yukihiro Ohya, Takahisa Murata, Kiwako Yamamoto-Hanada

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引用次数: 0

Abstract

Background: The prevalence of food allergies among children is on the rise, presenting with a spectrum of severity from mild cases to those resulting in anaphylaxis. Ensuring the safe progression of home-based food ingestion is essential in managing food allergy. While the oral food challenge (OFC) test ideally confirms the threshold and tolerated dose, past findings indicated that about 30% of children who passed peanut OFCs experienced peanut-related allergic reactions when introducing peanuts at home.

Objective: It is presumed that the immune reactions occurring within individual patients vary in levels according to the situation. To date, no reports have objectively examined these conditions.

Material and methods: We present the symptoms and validation of an objective biomarker in eight pediatric cases during home introduction of food allergens. The urinary Prostaglandin D metabolite (PGDM) was measured as a noninvasive biomarker.

Results: Some cases exhibited mild symptoms and elevated urinary PGDM levels during home introduction despite ingesting half the dose that confirmed as safe during OFC.

Conclusion: It underscores the importance of considering individual variability in determining food allergy thresholds.

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揭示个体阈值的异质性：在食物过敏反应中使用尿前列腺素D2代谢物进行验证。

背景：儿童食物过敏的患病率呈上升趋势，呈现出从轻度病例到导致过敏反应的严重程度。确保家庭食物摄入的安全进行对于控制食物过敏至关重要。虽然口服食物挑战（OFC）测试理想地确认了阈值和耐受剂量，但过去的研究结果表明，在通过花生OFC测试的儿童中，约有30%在家中引入花生时出现了与花生相关的过敏反应。目的：假定患者个体内发生的免疫反应水平随情况不同而不同。迄今为止，没有报告客观地审查了这些情况。材料和方法：我们介绍了8例在家中引入食物过敏原的儿科病例的症状和客观生物标志物的验证。尿前列腺素D代谢物（PGDM）作为一种无创生物标志物进行测量。结果：尽管在OFC期间摄入了确认安全剂量的一半，但一些病例在家庭引入时表现出轻微的症状和尿PGDM水平升高。结论：这强调了在确定食物过敏阈值时考虑个体差异的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergologia et immunopathologia 医学-过敏

CiteScore

3.70

自引率

0.00%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.