Análisis sobre la actividad in vitro de delafloxacino frente a bacteroides y sus posibles aplicaciones clínicas

IF 2.2 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI:10.1016/j.eimc.2025.503060

Maialen Larrea Ayo , Iker Alonso González , Regino Rodríguez Álvarez , Maider Zuriarrain Alonso , Clara Lejarraga Cañas , Begoña Vilar Achabal

{"title":"Análisis sobre la actividad in vitro de delafloxacino frente a bacteroides y sus posibles aplicaciones clínicas","authors":"Maialen Larrea Ayo , Iker Alonso González , Regino Rodríguez Álvarez , Maider Zuriarrain Alonso , Clara Lejarraga Cañas , Begoña Vilar Achabal","doi":"10.1016/j.eimc.2025.503060","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Resistance to β-lactams has risen globally among <em>Bacteroides</em> species. Consequently, delafloxacin has emerged as a therapeutic alternative against these microorganisms. The main objective of this study is to analyse the MIC of delafloxacin in <em>Bacteroides</em> spp. isolates and compare it with commonly used anaerobic antimicrobial agents.</div></div><div><h3>Method</h3><div>The susceptibility of delafloxacin and other anaerobic antibiotics was assessed in 370 isolates of the genus <em>Bacteroides</em> and MIC<sub>50</sub> and MIC<sub>90</sub> values were determined for all antibiotics.</div></div><div><h3>Results</h3><div>In <em>Bacteroides</em> spp. and the <em>Bacteroides fragilis</em> <em>sensu stricto</em> group the MIC<sub>50</sub> values for delafloxacin were lower than those of other antibiotics, except for tigecycline and metronidazole.</div></div><div><h3>Conclusion</h3><div>Given the potent <em>in vitro</em> anaerobic activity and its broad spectrum, delafloxacin may represent a favourable alternative in the treatment of mixed bacterial infections, particularly those involving multidrug-resistant strains.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"44 3","pages":"Article 503060"},"PeriodicalIF":2.2000,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Enfermedades infecciosas y microbiologia clinica","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0213005X25002745","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Resistance to β-lactams has risen globally among Bacteroides species. Consequently, delafloxacin has emerged as a therapeutic alternative against these microorganisms. The main objective of this study is to analyse the MIC of delafloxacin in Bacteroides spp. isolates and compare it with commonly used anaerobic antimicrobial agents.

Method

The susceptibility of delafloxacin and other anaerobic antibiotics was assessed in 370 isolates of the genus Bacteroides and MIC₅₀ and MIC₉₀ values were determined for all antibiotics.

Results

In Bacteroides spp. and the Bacteroides fragilis sensu stricto group the MIC₅₀ values for delafloxacin were lower than those of other antibiotics, except for tigecycline and metronidazole.

Conclusion

Given the potent in vitro anaerobic activity and its broad spectrum, delafloxacin may represent a favourable alternative in the treatment of mixed bacterial infections, particularly those involving multidrug-resistant strains.

查看原文本刊更多论文

甲氟沙星对细菌的体外活性及其可能的临床应用分析

在全球范围内，拟杆菌种对β-内酰胺的耐药性已经上升。因此，德拉沙星已成为一种治疗这些微生物的替代品。本研究的主要目的是分析德拉沙星在拟杆菌中的MIC，并将其与常用的厌氧抗菌药物进行比较。方法测定370株拟杆菌属病原菌对德拉沙星等厌氧抗生素的敏感性，并测定所有抗生素的MIC50和MIC90值。结果在拟杆菌属和严格敏感脆弱拟杆菌组中，德拉沙星的MIC50值低于除替加环素和甲硝唑外的其他抗生素。结论德拉沙星具有良好的体外厌氧活性和广谱性，可能是治疗混合细菌感染，特别是耐多药菌株感染的良好选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Enfermedades infecciosas y microbiologia clinica 医学-传染病学

CiteScore

2.10

自引率

8.00%

发文量

194

审稿时长

29 days

期刊介绍： Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.