Psychosocial impact of chronic oral mucosal pain disorders: Associations with oral health related quality of life, anxiety, and depression

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2026-03-01 Epub Date: 2026-03-06 DOI:10.1016/j.jobcr.2026.101426

Nancy Jidiya , Anulatha Manne , Sravanthi Ennala , Krishnapuram Akshita , Dhanashree Kamble , Riya Anand , Isha Patel , Santosh R. Patil , Shikhar Daniel

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引用次数: 0

Abstract

Background

Chronic oral mucosal pain disorders, including Burning Mouth Syndrome (BMS), Oral Lichen Planus (OLP), Atypical Odontalgia, and Persistent Idiopathic Facial Pain, are debilitating conditions that significantly impair oral health–related quality of life (OHRQoL). These disorders are frequently associated with psychological distress, particularly anxiety and depression; however, studies integrating assessments of OHRQoL with psychological morbidity remain limited.

Objective

To evaluate the impact of chronic oral mucosal pain disorders on OHRQoL, anxiety, and depression, and to identify psychological predictors of impaired quality of life.

Methods

A case–control study was conducted involving 52 patients with chronic oral mucosal pain disorders and 52 age- and sex-matched healthy controls. OHRQoL was assessed using the Oral Health Impact Profile–14 (OHIP-14), and psychological distress was measured using the Hospital Anxiety and Depression Scale (HADS). Group comparisons were performed using independent t-tests and chi-square tests. Multivariable linear regression identified independent predictors of OHIP-14 scores, and receiver operating characteristic (ROC) analysis evaluated the ability of OHIP-14 to detect depression.

Results

Patients showed significantly higher OHIP-14 scores than controls (28.3 ± 6.0 vs. 11.7 ± 5.0; p < 0.0001). Clinically relevant anxiety and depression were present in 84.6% and 80.8% of patients, respectively. Anxiety and depression independently predicted poorer OHRQoL, while demographic factors and symptom duration were not significant. OHIP-14 demonstrated good diagnostic accuracy for depression (Area under the curve (AUC) = 0.85).

Conclusion

Chronic oral mucosal pain disorders (COMPD) are associated with marked impairment in quality of life and substantial psychological burden, underscoring the need for routine psychological screening in oral medicine practice.

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慢性口腔黏膜疼痛障碍的社会心理影响：与口腔健康相关的生活质量、焦虑和抑郁的关系

慢性口腔黏膜疼痛疾病，包括灼口综合征（BMS）、口腔扁平苔藓（OLP）、非典型牙痛和持续性特发性面部疼痛，是一种严重损害口腔健康相关生活质量（OHRQoL）的衰弱性疾病。这些疾病通常与心理困扰有关，特别是焦虑和抑郁；然而，将OHRQoL评估与心理发病率相结合的研究仍然有限。目的评价慢性口腔黏膜疼痛障碍对OHRQoL、焦虑和抑郁的影响，并确定生活质量受损的心理预测因素。方法对52例慢性口腔黏膜疼痛障碍患者和52例年龄、性别匹配的健康对照进行病例对照研究。使用口腔健康影响量表-14 （OHIP-14）评估OHRQoL，使用医院焦虑和抑郁量表（HADS）测量心理困扰。采用独立t检验和卡方检验进行组间比较。多变量线性回归确定OHIP-14评分的独立预测因子，受试者工作特征（ROC）分析评估OHIP-14检测抑郁的能力。结果患者OHIP-14评分明显高于对照组（28.3±6.0∶11.7±5.0;p < 0.0001）。临床相关焦虑和抑郁分别占84.6%和80.8%。焦虑和抑郁独立预测较差的OHRQoL，而人口统计学因素和症状持续时间不显著。OHIP-14对抑郁症有较好的诊断准确性（曲线下面积(AUC) = 0.85）。结论慢性口腔黏膜疼痛障碍（COMPD）与明显的生活质量下降和严重的心理负担相关，强调在口腔医学实践中进行常规心理筛查的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.