Global research status and hot-spots of Sirt1 in aging: a bibliometric analysis based from 2005 to 2024

IF 1.7 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2026-03-01 Epub Date: 2026-03-06 DOI:10.1016/j.cegh.2026.102325

Shiyao Liu , Congcong Song , Ziyi Liu , Yushan Li , Huimei Chen , Wei Chen , Na Wang

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引用次数: 0

Abstract

Background

Aging is a complex physiological process, regulated by multiple intertwined mechanisms. In this process, Sirt1 played a vital role with evidences increasing continually. Given the rapid expansion of research in this area, a comprehensive overview of the intellectual landscape is needed to guide future investigations. Based on, we conducted a bibliometric analysis of the relevant literature and visualized the results. Our study aimed to consolidate the current knowledge and provide insights into evolving research trends, thereby contributing to a deeper understanding of Sirt1's roles in aging process.

Methods

On August 14th, 2024, we retrieved 2434 issues in Web of Science Core Collection (searching period from 2005 to 2024). Using VOSviewer, Citespace and bibliometrix, we analyzed these records in terms of annual publications/citations, spatiotemporal distribution, collaborations between regions/institutions/authors, co-references, and keywords.

Result

We identified a stable development trend of researching on Sirt1 and aging. In the last 2 decades, the average growth rate of publication numbers was 34.52%, while in recent 5 years it fell to 10.8%. So far, China and the United States were more conductive and influential in this field. Their publications accounted for 39.56% and 26.17%, respectively. Of interests, since Hungary's publication numbers just accounted for 7% of the publications worldly, it had the strongest average citations. Besides, some institutions and countries had varieties of publications, but weak link strength, meaning further collaborations of them were needed in future study. Importantly, keywords analysis indicated that oxidative stress and calorie restriction were the main hot-spots of this field. Besides, inflammation, DNA damage, metabolism, mitochondrial dysfunction and autophagy might be new research directions in Sirt1 and aging.

Conclusions

Above all, this study provided further insights into recent advances and future progression in researches on Sirt1 and aging.

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Sirt1在老龄化中的全球研究现状与热点：基于2005 - 2024年的文献计量学分析

衰老是一个复杂的生理过程，受多种相互交织的机制调控。在这一过程中，Sirt1发挥了至关重要的作用，证据不断增加。鉴于这一领域的研究迅速扩大，需要对智力景观进行全面的概述，以指导未来的研究。在此基础上，我们对相关文献进行了文献计量学分析，并将结果可视化。我们的研究旨在巩固现有的知识，并为不断发展的研究趋势提供见解，从而有助于更深入地了解Sirt1在衰老过程中的作用。方法于2024年8月14日检索Web of Science核心馆藏2434期（检索期2005 - 2024）。利用VOSviewer、Citespace和bibliometrix对这些文献进行了年度发表/被引、时空分布、地区/机构/作者合作、共同参考文献和关键词等方面的分析。结果Sirt1与衰老的研究有稳定的发展趋势。在过去的20年里，出版数量的平均增长率为34.52%，而近5年下降到10.8%。到目前为止，中美两国在这一领域的导向性和影响力更大。发表量占比分别为39.56%和26.17%。有趣的是，由于匈牙利的出版物数量仅占全球出版物的7%，它的平均引用量最高。此外，一些机构和国家的出版物种类繁多，但链接强度较弱，需要在未来的研究中进一步合作。重要的是，关键词分析表明，氧化应激和热量限制是该领域的主要热点。此外，炎症、DNA损伤、代谢、线粒体功能障碍、自噬等可能是Sirt1与衰老研究的新方向。总之，本研究为Sirt1与衰老研究的最新进展和未来进展提供了进一步的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.