Knowledge, attitudes, and practices regarding human papillomavirus vaccination among teenage girls with sickle cell disease at Usmanu Danfodiyo University teaching hospital, Sokoto, Nigeria

IF 1.7 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2026-03-01 Epub Date: 2026-02-12 DOI:10.1016/j.cegh.2026.102318

Ibrahim Abdulqadir , Ahmad Abubakar , Muhammad Umar Sa'id , Hadiza Muhammad Ango , Jonas-Attabo Samson Apeh , Abdallah Ahmed Adam Belal , Adam Dawria , Ali Mohieldin , Abdelsalam Mohamed Daoud Yahya , Sami M. HasapAla , Aeshah Alshehri , Fatima Garba Muhammad , Bello Arkilla Magaji

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引用次数: 0

Abstract

Background

Sickle Cell Disease (SCD) impairs immune function and increases susceptibility to infections such as Human Papillomavirus (HPV), a primary cause of cervical cancer. Both conditions pose major public health challenges in Nigeria, where overall HPV awareness and vaccine uptake remain low. This study assessed the knowledge, attitudes, and practices (KAP) regarding HPV vaccination among teenage girls with confirmed SCD in Sokoto State, aiming to inform targeted preventive strategies.

Methods

This cross-sectional study was conducted at Usmanu Danfodiyo University Teaching Hospital (UDUTH), Sokoto, involving 85 teenage girls with confirmed SCD. Data were collected using a pretested semi-structured questionnaire administered via ODK, and analysed using descriptive and inferential statistics with Excel and Jamovi respectively.

Results

The 85 participants (mean age 15.6 years) were predominantly of the HbSS phenotype (82%). They were mostly diagnosed before the age of five (93%) and managed with hydroxyurea (79%). HPV knowledge was poor: only 8% correctly linked HPV to cervical cancer or knew the correct vaccination age. While 96% feared cervical cancer, fewer than half considered the vaccine useful (47%) or safe (48%). Despite 54% expressing willingness, the overall vaccine uptake was low (12%). Significant associations were observed between KAP and variables including age, education, and history of painful SCD crisis.

Conclusion

These findings reveal significant gaps in HPV vaccine knowledge and uptake among high-risk population. We recommend immediate, targeted awareness campaigns, government support, and the integration of HPV vaccination into routine SCD hospital care programs.

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尼日利亚索科托Usmanu Danfodiyo大学教学医院镰状细胞病少女中关于人乳头瘤病毒疫苗接种的知识、态度和做法

背景镰状细胞病（SCD）损害免疫功能，增加对人类乳头瘤病毒（HPV）等感染的易感性，HPV是宫颈癌的主要原因。这两种情况对尼日利亚的公共卫生构成重大挑战，在尼日利亚，人乳头瘤病毒的总体认识和疫苗接种率仍然很低。本研究评估了索科托州确诊SCD的少女中关于HPV疫苗接种的知识、态度和实践（KAP），旨在为有针对性的预防策略提供信息。方法横断面研究在索科托Usmanu Danfodiyo大学教学医院（UDUTH）进行，涉及85名确诊SCD的少女。采用ODK预测半结构化问卷收集数据，分别使用Excel和Jamovi进行描述性统计和推理统计分析。结果85例参与者（平均年龄15.6岁）以HbSS表型为主（82%）。他们大多在5岁前被诊断出来（93%），并用羟基脲治疗（79%）。HPV知识贫乏：只有8%的人正确地将HPV与宫颈癌联系起来，或者知道正确的疫苗接种年龄。虽然96%的人担心宫颈癌，但只有不到一半的人认为疫苗有用（47%）或安全（48%）。尽管54%的人表示愿意接种疫苗，但总体疫苗接种率很低（12%）。KAP与年龄、教育程度和疼痛性SCD危象史等变量之间存在显著关联。结论高危人群在HPV疫苗知识和接种方面存在明显差距。我们建议立即开展有针对性的宣传活动，政府支持，并将HPV疫苗接种纳入常规SCD医院护理计划。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.