Preparation and synthetic applications of polyfluoroalkanethioamides✰

Abstract

Polyfluoroalkyl-substituted thioamides have attracted growing interest over the past two decades and have currently emerged as versatile fluorine-containing building-blocks. In the first part of the review, the different synthetic approaches developed so far for the preparation of polyfluoroalkanethioamides have been described and analyzed, with emphasis on their scope and limitations. In the second part, the chemical properties of polyfluoroalkanethioamides are discussed, highlighting a variety of their applications in the synthesis of organofluorine compounds that underscore their high synthetic potential. The review covers the literature published from 1956, when the synthesis of polyfluoroalkanethioamides was first reported, until the present. The bibliography contains 121 references.