Anthropometric, sociodemographic and metabolic factors associated with clinically expressed insulin resistance in individuals with type 2 diabetes

IF 1.7 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2026-03-01 Epub Date: 2026-02-12 DOI:10.1016/j.cegh.2026.102322

Rudminaitė Emilė, Čypaitė Gabrielė, Šimonienė Diana

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引用次数: 0

Abstract

Clinically expressed insulin resistance (IR) in type 2 diabetes (T2D) patients usually leads to poor hyperglycaemia control and progression of complications.

Aims

to evaluate how selected sociodemographic, metabolic and anthropometric factors are linked to expressed IR among T2D patients and assess the clinical tools for IR evaluation.

Methods

A sample of 100 T2D patients aged 18 - 80 years old was divided based on their daily insulin requirement into case (>1IU/kg/d) and control (<1IU/kg/d) groups. The data was obtained by interviewing patients using original questionnaires, analysing their medical history, performing clinical examination and blood tests.

Results

The case group subjects were younger (p < 0.001) and the duration of their diabetes was shorter (p < 0.001). The patients with expressed IR more often had metabolic syndrome (p = 0.005) and dyslipidaemia (86.2% vs. 67.8%, p = 0.018), particularly hypertriglyceridemia. All patients with expressed insulin resistance (IR) exhibited elevated levels of visceral adipose tissue (VAT >454 g), and the prevalence of visceral obesity was significantly higher in this group compared to the control group (100% vs. 72.7%, p = 0.032). High insulin requirement strongly correlated with HOMA-IR and eGDR in patients with T2D and could be used in determining IR.

Conclusions

Patients with T2D and expressed IR were younger and the duration of diabetes was shorter. The prevalence of metabolic syndrome and dyslipidemia—specifically hypertriglyceridemia—was higher among individuals with expressed IR. Although the percentage of total body fat was comparable between groups, the amount of visceral adipose tissue was significantly greater in patients with expressed IR.

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与2型糖尿病患者临床表达的胰岛素抵抗相关的人体测量学、社会人口学和代谢因素

2型糖尿病（T2D）患者临床表达的胰岛素抵抗（IR）通常导致高血糖控制不良和并发症的进展。目的评估选定的社会人口学、代谢和人体测量因素如何与T2D患者的IR表达相关，并评估用于IR评估的临床工具。方法将100例年龄在18 ~ 80岁的t2dm患者按每日胰岛素需用量分为病例组（1IU/kg/d）和对照组（1IU/kg/d）。数据是通过使用原始问卷采访患者、分析其病史、进行临床检查和血液检查获得的。结果病例组患者年龄较轻（p < 0.001），病程较短（p < 0.001）。IR表达的患者更常发生代谢综合征（p = 0.005）和血脂异常（86.2% vs. 67.8%, p = 0.018），特别是高甘油三酯血症。所有胰岛素抵抗（IR）表达的患者都表现出内脏脂肪组织（VAT >454 g）水平升高，与对照组相比，该组内脏肥胖的患病率明显更高（100% vs. 72.7%, p = 0.032）。高胰岛素需要量与T2D患者HOMA-IR和eGDR密切相关，可用于确定IR。结论伴有T2D和IR表达的患者年龄较小，病程较短。代谢综合征和血脂异常（特别是高甘油三酯血症）的患病率在IR表达的个体中更高。虽然两组之间的总脂肪百分比相当，但表达IR的患者内脏脂肪组织的数量明显更多。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.