Psychiatric comorbidity in DiGeorge association: Suicidal ideation and bipolar disorder

Abstract

DiGeorge syndrome, also known as 22q11.2 deletion syndrome, is a multisystem condition associated with congenital cardiac defects, craniofacial abnormalities, immune dysfunction, endocrine disturbances, and a high lifetime risk of psychiatric disorders. Bipolar I Disorder is a severe mood disorder with a substantially elevated risk of suicidal ideation and attempts, especially during manic episodes with psychotic features. This report describes a woman in her 20’s with 22q11.2 Deletion Syndrome and Bipolar I Disorder who presented with acute suicidal ideation in the context of a manic episode. She responded to inpatient stabilization and responded well to valproic acid and olanzapine. This case highlights the substantial clinical impact of psychiatric illness in 22q11.2 deletion syndrome and reinforces the need for heightened attention to mood instability and suicide risk in affected individuals.