Real-time phase-contrast MRI can be used to quantify cerebrovascular reserve capacity – a comparative study to neurovascular ultrasound in healthy subjects

Q4 Neuroscience

Neuroimage. Reports Pub Date : 2026-03-01 Epub Date: 2026-02-25 DOI:10.1016/j.ynirp.2026.100332

Christian Horstmann , Sabine Hofer , Peter Dechent , Mathias Bähr , Ilko Maier

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Abstract

Background

Cerebrovascular reserve capacity (CVRC) is reduced in patients with advanced large artery atherosclerosis (LAA) and represents a risk factor for ischemic stroke. Aim of this study was to compare CVRC testing derived by neurovascular ultrasound (nvUS) and real-time phase-contrast MRI (RT-PC MRI).

Methods

In this study 25 subjects (age 33±13 years) without any LAA were first investigated with nvUS followed by RT-PC MRI performing a standardized hyperventilation-apnea-test. CVRC was determined in the medial (MCA) and posterior cerebral artery (PCA) using transtemporal nvUS and RT-PC MRI at 25 fps temporal resolution, 0.8×0.8 mm² in plane resolution and a slice thickness of 6 mm during free breathing. For statistical analysis a paired t-test and a pearson correlation were used at α=0.05.

Results

Overall, peak-systolic velocities (PSV) and end-diastolic velocities (EDV) showed lower values for the RT-PC MRI as compared to nvUS. The PSV-decrease during hyperventilation relative to baseline was higher in RT-PC MRI measurements (22% (MCA) and 26% (PCA) for nvUS vs. 34% (MCA) and 39% (PCA) for RT-PC MRI, p<0.001), while the relative PSV-increase from hyperventilation to apnea was comparable between both modalities with a mean difference of <10% (62% (MCA) and 78% (PCA) for nvUS vs. 70% (MCA) and 84% (PCA) for RT-PC MRI, p=0.171 for MCA and p=0.324 for PCA).

Conclusions

Both nvUS and RT-PC MRI based CVRC measurements showed reliable de- and increases in PSV during the standardized breathing protocol. RT-PC MRI represents a promising technique to determine CVRC in various intracranial vessels.

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实时相对比MRI可用于量化脑血管储备容量-与健康受试者神经血管超声的比较研究

背景：晚期大动脉粥样硬化（LAA）患者的脑血管储备容量（CVRC）降低，是缺血性卒中的危险因素。本研究的目的是比较神经血管超声（nvUS）和实时相位对比MRI （RT-PC MRI）得出的CVRC检测结果。方法在本研究中，25名无LAA的受试者（年龄33±13岁）首先使用nvUS进行调查，然后使用RT-PC MRI进行标准化的过度通气-呼吸暂停测试。在自由呼吸时，使用经颞叶nvUS和RT-PC MRI以25 fps的时间分辨率，0.8×0.8 mm2的平面分辨率和6 mm的切片厚度测定大脑内侧动脉（MCA）和大脑后动脉（PCA）的CVRC。统计分析采用配对t检验和pearson相关性，α=0.05。结果总的来说，与nvUS相比，RT-PC MRI显示收缩峰值速度（PSV）和舒张末期速度（EDV）值较低。在RT-PC MRI测量中，过度通气期间相对于基线的psv下降更高(nvUS为22% （MCA）和26% (PCA)，而RT-PC MRI为34% （MCA）和39% (PCA), p<0.001)，而过度通气到呼吸暂停的相对psv增加在两种模式之间是相当的，平均差异为<；10% (nvUS为62% （MCA）和78% （PCA)， RT-PC MRI为70% （MCA）和84% (PCA)， MCA为p=0.171， PCA为p=0.324）。结论：在标准化呼吸方案中，nvUS和基于RT-PC MRI的CVRC测量均显示PSV的可靠降低和增加。RT-PC MRI是一种很有前途的检测颅内各种血管CVRC的技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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