Magnetic resonance image features of children ependymoma and correlation between programmed cell death ligand 1 expression and pathological features in tumor tissues

IF 2.5 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI:10.1016/j.jrras.2026.102195

Ling Li , Mingjun Zheng , Weixia Meng

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引用次数: 0

Abstract

Background and objective

The incidence of ependymoma is higher in children than in adults, and it is a major cause of poor prognosis in pediatric patients. This study aimed to analyze the multimodal magnetic resonance imaging (MRI) characteristics of pediatric ependymoma and the correlation between programmed death-ligand 1 (PD-L1) expression in tumor tissues and clinicopathological features.

Methods

Fifty pediatric patients with pathologically confirmed ependymoma were enrolled. MRI, diffusion-weighted imaging (DWI), and proton magnetic resonance spectroscopy (¹H-MRS) features were evaluated according to WHO grading. PD-L1 positivity was detected in both lesional and adjacent normal tissues, and its relationship with clinicopathological characteristics and survival rate was analyzed.

Results

apparent diffusion coefficient (ADC)min, rADC, and NAA/Cr ratios were significantly lower in WHO grade III patients than in grades I, II, and II–III, while Cho/Cr was significantly higher (P < 0.05). The PD-L1 positivity rate was significantly higher in tumor tissues (52 %) than in adjacent normal tissues (18 %) (P < 0.05). PD-L1 expression was significantly elevated in patients with tumor diameter ≥2 cm, partial resection, moderate-to-poor differentiation, and WHO grade III (P < 0.05). At the 10-month follow-up, the survival rate of PD-L1-positive patients (57.7 %) was significantly lower than that of PD-L1-negative patients (83.3 %) (P < 0.05).

Conclusion

DWI can differentiate between ependymoma grades and improve preoperative diagnostic efficiency. Elevated PD-L1 expression in tumor tissue is associated with aggressive features and may serve as a marker for assessing short-term prognosis in pediatric ependymoma. MRI-DWI and ¹H-MRS parameters (ADCmin, rADC, NAA/Cr, Cho/Cr) reflect tumor grade and malignancy, while PD-L1 expression correlates with invasiveness and outcome. Their combination provides a more comprehensive basis for disease evaluation and prognostic assessment in pediatric ependymoma.

查看原文本刊更多论文

儿童室管膜瘤的磁共振影像特征及肿瘤组织中程序性细胞死亡配体1表达与病理特征的关系

背景与目的室管膜瘤在儿童中的发病率高于成人，是儿童患者预后不良的主要原因。本研究旨在分析小儿室管膜瘤的多模态磁共振成像（MRI）特征及肿瘤组织中程序性死亡配体1 （programmed death-ligand 1, PD-L1）表达与临床病理特征的相关性。方法选取50例经病理证实的室管膜瘤患儿。MRI，弥散加权成像（DWI）和质子磁共振波谱（1H-MRS）特征根据WHO分级进行评估。PD-L1阳性在病变及邻近正常组织中均检测到，并分析其与临床病理特征及生存率的关系。结果WHO三级患者表观弥散系数（ADC）min、rADC、NAA/Cr比值显著低于ⅰ、ⅱ、ⅱ-ⅲ级患者，Cho/Cr比值显著高于ⅰ、ⅱ、ⅲ级患者（P < 0.05）。肿瘤组织中PD-L1阳性率（52%）明显高于邻近正常组织（18%）（P < 0.05）。PD-L1表达在肿瘤直径≥2 cm、部分切除、中低分化、WHO分级III级患者中显著升高（P < 0.05）。随访10个月时，pd - l1阳性患者的生存率（57.7%）显著低于pd - l1阴性患者的生存率（83.3%）（P < 0.05）。结论dwi可鉴别室管膜瘤分级，提高术前诊断效率。肿瘤组织中PD-L1表达升高与侵袭性特征相关，可作为评估儿童室管膜瘤短期预后的标志。MRI-DWI和1H-MRS参数（ADCmin、rADC、NAA/Cr、Cho/Cr）反映肿瘤分级和恶性程度，而PD-L1表达与侵袭性和预后相关。它们的结合为儿科室管膜瘤的疾病评估和预后评估提供了更全面的依据。

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来源期刊

Journal of Radiation Research and Applied Sciences MULTIDISCIPLINARY SCIENCES-

自引率

5.90%

发文量

130

审稿时长

16 weeks

期刊介绍： Journal of Radiation Research and Applied Sciences provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and applications of nuclear, radiation and isotopes in biology, medicine, drugs, biochemistry, microbiology, agriculture, entomology, food technology, chemistry, physics, solid states, engineering, environmental and applied sciences.