Yan Xing, Rujing Shi, Yulian Li, Run Cai, Tianwei Ma, Xinhai Yuan, Liu Li, Ziyun Jiang, Wenjing Gao
{"title":"Human papillomavirus awareness and vaccination willingness among male community residents in Beijing based on the Health Belief Model.","authors":"Yan Xing, Rujing Shi, Yulian Li, Run Cai, Tianwei Ma, Xinhai Yuan, Liu Li, Ziyun Jiang, Wenjing Gao","doi":"10.1080/21645515.2026.2641328","DOIUrl":null,"url":null,"abstract":"<p><p>Following the January 2025 approval of the first male HPV vaccine in the Chinese mainland, we investigated vaccination willingness and its influencing factors among community-dwelling men. We conducted a cross-sectional study in Beijing, recruiting 480 community-based male residents and 399 men who have sex with men (MSM). Participants completed a questionnaire assessing HPV knowledge and the Health Belief Model (HBM) constructs. Multivariable logistic regression was performed to identify determinants of willingness. We found a high level of vaccination willingness, which was notably higher among MSM (90.73%) than the community-recruited male population (87.29%). Critically, willingness surpassed awareness, indicating significant latent demand despite low overall HPV knowledge. HBM analysis showed that perceived benefits promoted willingness in both groups, while self-efficacy of prevention paradoxically acted as an inhibitor. MSM reported higher perceived susceptibility and benefits, but lower severity, compared to community-recruited men. Determinants diverged significantly: income and sexual behavior were unique drivers for community-recruited men, whereas HPV knowledge and STI self-testing drove willingness in MSM. This study confirms high post-approval vaccination willingness but highlights distinct influencing factors. Findings suggest the need for differentiated strategies: universal approaches should highlight vaccine benefits to convert latent demand, while targeted education for MSM must focus on improving knowledge accuracy.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"22 1","pages":"2641328"},"PeriodicalIF":4.2000,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973470/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Vaccines & Immunotherapeutics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/21645515.2026.2641328","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/3/9 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Following the January 2025 approval of the first male HPV vaccine in the Chinese mainland, we investigated vaccination willingness and its influencing factors among community-dwelling men. We conducted a cross-sectional study in Beijing, recruiting 480 community-based male residents and 399 men who have sex with men (MSM). Participants completed a questionnaire assessing HPV knowledge and the Health Belief Model (HBM) constructs. Multivariable logistic regression was performed to identify determinants of willingness. We found a high level of vaccination willingness, which was notably higher among MSM (90.73%) than the community-recruited male population (87.29%). Critically, willingness surpassed awareness, indicating significant latent demand despite low overall HPV knowledge. HBM analysis showed that perceived benefits promoted willingness in both groups, while self-efficacy of prevention paradoxically acted as an inhibitor. MSM reported higher perceived susceptibility and benefits, but lower severity, compared to community-recruited men. Determinants diverged significantly: income and sexual behavior were unique drivers for community-recruited men, whereas HPV knowledge and STI self-testing drove willingness in MSM. This study confirms high post-approval vaccination willingness but highlights distinct influencing factors. Findings suggest the need for differentiated strategies: universal approaches should highlight vaccine benefits to convert latent demand, while targeted education for MSM must focus on improving knowledge accuracy.
期刊介绍:
(formerly Human Vaccines; issn 1554-8619)
Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics.
Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.