Advancements in Design and Application of Absorbable Materials for Orbital Fracture Reconstruction.

IF 4.3 2区 医学 Q2 CELL & TISSUE ENGINEERING
Zhangjun Ren, Chao Xiong, Hongfei Liao
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引用次数: 0

Abstract

Orbital fractures are a common type of maxillofacial trauma, and their functional and aesthetic reconstruction has long posed challenges in surgical repair. Traditional implant materials (such as autogenous bone, titanium mesh, and porous polyethylene) carry risks of long-term foreign body retention and associated complications. Absorbable materials overcome the drawbacks of permanent implants by providing temporary mechanical support during healing while gradually degrading, representing a significant advancement in orbital fracture repair. This article systematically reviews the design advancements and current applications of resorbable materials in orbital fracture reconstruction. It covers material classification (including properties of poly-L lactic acid [PLLA], polyglycolic acid, polycaprolactone [PCL], and their composites), biomechanical performance, degradation mechanisms, and their integration with precision technologies such as 3D printing, computer navigation, and external endoscopy for preoperative planning and intraoperative procedures. Clinical studies indicate that absorbable implants achieve repair outcomes comparable to permanent implants in small-to-medium and some complex orbital fractures, with the unique advantage of avoiding interference with growth and development in pediatric patients. Despite challenges including delayed inflammatory responses, mechanical strength limitations, and inadequate radiopacity, novel material designs (e.g., uncalcined hydroxyapatite/PLLA composites) and hybrid technologies (e.g., incorporating functional factors such as bone morphogenetic protein-2) are continuously enhancing their performance. Future directions encompass developing smart biomaterials, deepening digital technology integration, advancing long-term multicenter clinical studies, and optimizing cost-effectiveness strategies. Absorbable materials are poised to become a mainstream choice for orbital fracture repair.Impact StatementThis review highlights the transformative role of absorbable materials in orbital fracture reconstruction. By providing temporary support and then degrading, they eliminate long-term risks of permanent implants. The integration of advanced composites (e.g., u-HA/PLLA) and precision technologies such as 3D printing enables superior, patient-specific outcomes. This research consolidates evidence for their efficacy, particularly in pediatric cases, and charts a future course toward smart biomaterials and deeper digital integration, establishing them as a potential new standard of care and significantly advancing the field of maxillofacial surgery.

眼眶骨折重建中可吸收材料的设计与应用进展。
眶部骨折是颌面部常见的创伤类型,其功能和美学重建一直是外科修复的挑战。传统的植入材料(如自体骨、钛网和多孔聚乙烯)存在长期异物潴留和相关并发症的风险。可吸收材料克服了永久性植入物的缺点,在愈合过程中提供暂时的机械支持,同时逐渐降解,代表了眶骨折修复的重大进步。本文系统地综述了可吸收材料在眼眶骨折重建中的设计进展和应用现状。它涵盖了材料分类(包括聚l乳酸[PLLA]、聚乙醇酸、聚己内酯[PCL]及其复合材料的性质)、生物力学性能、降解机制,以及它们与3D打印、计算机导航、外部内窥镜等精密技术的结合,用于术前规划和术中操作。临床研究表明,可吸收性植入物修复中小型及部分复杂眶内骨折的效果与永久性植入物相当,具有避免干扰儿科患者生长发育的独特优势。尽管面临包括炎症反应延迟、机械强度限制和不透明等挑战,但新型材料设计(例如未煅烧的羟基磷灰石/PLLA复合材料)和混合技术(例如纳入骨形态发生蛋白-2等功能因子)正在不断提高其性能。未来的发展方向包括发展智能生物材料,深化数字技术整合,推进长期多中心临床研究,优化成本效益策略。可吸收材料有望成为眼眶骨折修复的主流选择。本综述强调了可吸收材料在眶内骨折重建中的变革性作用。通过提供暂时的支持,然后降解,它们消除了永久植入物的长期风险。先进复合材料(如u-HA/PLLA)和精密技术(如3D打印)的集成可实现卓越的患者特异性结果。本研究巩固了其有效性的证据,特别是在儿科病例中,并绘制了智能生物材料和更深层次数字集成的未来路线,将其确立为潜在的新护理标准,并显着推进颌面外科领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tissue Engineering. Part B, Reviews
Tissue Engineering. Part B, Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
12.80
自引率
1.60%
发文量
150
期刊介绍: Tissue Engineering Reviews (Part B) meets the urgent need for high-quality review articles by presenting critical literature overviews and systematic summaries of research within the field to assess the current standing and future directions within relevant areas and technologies. Part B publishes bi-monthly.
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