Quantitative Choroid Plexus Gadolinium Enhancement Is Related to Diffuse Brain Tissue Injury in Multiple Sclerosis

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging Pub Date : 2026-03-09 DOI:10.1111/jon.70132

Sneha Senthil, Ian Tagge, Dumitru Fetco, Cheng Hsun Hsieh, Haz-Edine Assemlal, Zahra Karimaghaloo, Emily Fetco, G. R. Wayne Moore, Douglas L. Arnold, David A. Rudko, Sridar Narayanan

{"title":"Quantitative Choroid Plexus Gadolinium Enhancement Is Related to Diffuse Brain Tissue Injury in Multiple Sclerosis","authors":"Sneha Senthil, Ian Tagge, Dumitru Fetco, Cheng Hsun Hsieh, Haz-Edine Assemlal, Zahra Karimaghaloo, Emily Fetco, G. R. Wayne Moore, Douglas L. Arnold, David A. Rudko, Sridar Narayanan","doi":"10.1111/jon.70132","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Recent studies suggest that disruptions of the blood–cerebrospinal fluid (CSF) barrier within the choroid plexus (ChP) may contribute to multiple sclerosis (MS) pathogenesis. We investigated the relationship between a quantitative marker of ChP enhancement and markers of focal and diffuse brain tissue injury in MS.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A group of 34 MS participants and 21 healthy participants underwent 7T MRI including magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) and fluid attenuated inversion recovery (FLAIR) acquisitions. The MS group received contrast, and delta T1 (ΔT1) maps were computed to assess enhancement. ChP, white matter lesions (WML), normal-appearing white matter (NAWM), and gray matter (GM) were segmented. Pre-contrast quantitative T1 (qT1) values were compared between groups, and linear regression with mean ChP ΔT1 was performed for WML volume and pre-gadolinium (Gd) mean qT1 of WML, NAWM, and GM.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Mean qT1 of ChP, NAWM, and GM, as well as ChP volume, were higher in MS compared to controls (<i>p</i> < 0.001). ChP ΔT1 was significantly associated with pre-Gd qT1 of NAWM (<i>β</i> = 0.20, <i>R<sup>2</sup></i> = 0.54, <i>p</i> < 0.001) and GM (<i>β</i> = 0.18, <i>R<sup>2</sup></i> = 0.49, <i>p</i> < 0.001), but not WML volume (<i>p</i> = 0.3) or WML qT1 (<i>p</i> = 0.05).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The association between ChP enhancement and diffuse tissue injury, together with elevated qT1 values and ChP volumes in MS, supports a mechanism of brain injury involving CSF-mediated toxicity distinct from classic lesion pathology in MS.</p>\n </section>\n </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"36 2","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972605/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neuroimaging","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jon.70132","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Recent studies suggest that disruptions of the blood–cerebrospinal fluid (CSF) barrier within the choroid plexus (ChP) may contribute to multiple sclerosis (MS) pathogenesis. We investigated the relationship between a quantitative marker of ChP enhancement and markers of focal and diffuse brain tissue injury in MS.

Methods

A group of 34 MS participants and 21 healthy participants underwent 7T MRI including magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) and fluid attenuated inversion recovery (FLAIR) acquisitions. The MS group received contrast, and delta T1 (ΔT1) maps were computed to assess enhancement. ChP, white matter lesions (WML), normal-appearing white matter (NAWM), and gray matter (GM) were segmented. Pre-contrast quantitative T1 (qT1) values were compared between groups, and linear regression with mean ChP ΔT1 was performed for WML volume and pre-gadolinium (Gd) mean qT1 of WML, NAWM, and GM.

Results

Mean qT1 of ChP, NAWM, and GM, as well as ChP volume, were higher in MS compared to controls (p < 0.001). ChP ΔT1 was significantly associated with pre-Gd qT1 of NAWM (β = 0.20, R² = 0.54, p < 0.001) and GM (β = 0.18, R² = 0.49, p < 0.001), but not WML volume (p = 0.3) or WML qT1 (p = 0.05).

Conclusions

The association between ChP enhancement and diffuse tissue injury, together with elevated qT1 values and ChP volumes in MS, supports a mechanism of brain injury involving CSF-mediated toxicity distinct from classic lesion pathology in MS.

Abstract Image

查看原文本刊更多论文

定量脉络膜丛钆增强与多发性硬化症弥漫性脑组织损伤有关。

背景：最近的研究表明，脉络膜丛（ChP）内血脑脊液（CSF）屏障的破坏可能与多发性硬化症（MS）的发病机制有关。方法：选取34名多发性硬化症患者和21名健康人，分别行7T磁共振成像，包括磁化制备的2次快速采集梯度回波（MP2RAGE）和液体衰减反转恢复（FLAIR）成像。MS组接受对比，计算T1 （ΔT1）图以评估增强情况。对ChP、白质病变（WML）、正常白质（NAWM）、灰质（GM）进行分割。比较各组间对比前定量T1 （qT1）值，并对WML体积和WML、NAWM和GM的Gd前平均qT1 （ΔT1）进行线性回归。结果：MS组ChP、NAWM和GM的平均qT1以及ChP体积均高于对照组（p < 0.001）。ChP ΔT1与NAWM （β = 0.20, R2 = 0.54, p < 0.001）和GM （β = 0.18, R2 = 0.49, p < 0.001）的gd前qT1相关，但与WML体积（p = 0.3）和WML qT1无关（p = 0.05）。结论：ChP增强与弥漫性组织损伤之间的关联，以及MS中qT1值和ChP体积的升高，支持了一种涉及csf介导毒性的脑损伤机制，不同于MS的典型病变病理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!