Enhanced 2D Spiral Cine DENSE MRI Using Low-Rank Denoising for Improved Apparent Signal-to-Noise Ratio, Spatial Resolution, Efficiency, Accuracy, and Accessibility.
IF 3 3区 医学Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
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引用次数: 0
Abstract
Purpose: To develop a denoising technique for displacement encoding with stimulated echoes (DENSE) MRI that improves spatial resolution, efficiency, and accuracy, and enhances accessibility by implementing DENSE MRI at 0.55 T.
Methods: We developed a low-rank denoising technique, which leverages multidimensional spiral cine DENSE MRI data for empirical noise estimation via Monte Carlo simulation combined with automatic noise suppression. Thirty-six subjects (16 healthy, 20 with heart disease) were scanned at 3 T with breath-hold standard-resolution 2D cine DENSE (2.8 × 2.8 mm2) in a short-axis slice of the heart. In 10 healthy subjects, high-resolution DENSE with 1.2 × 1.2 mm2 was acquired. Apparent signal-to-noise ratio (SNR), phase SNR, scan efficiency (SNR per heartbeat per unit voxel size), and standard deviation of segmental circumferential myocardial strain (Ecc) were compared with Wilcoxon signed-rank tests (p < 0.05 considered significant). High-resolution and standard-resolution DENSE results were compared using Bland-Altman analysis. Lastly, we scanned seven healthy subjects at 0.55 T and 3 T, and compared Ecc results.
Results: Apparent magnitude SNR, phase SNR and scan efficiency were significantly improved after denoising in both standard-resolution and high-resolution DENSE (all p < 0.01). Bland-Altman analysis showed denoised high-resolution DENSE Ecc had smaller mean differences (non-denoised: 0.028 vs. denoised: 0.009) and narrower limits of agreement (non-denoised: [-0.072, 0.127] vs. denoised: [-0.048, 0.065]), indicating improved accuracy. Strain measurements from denoised DENSE at 0.55 T showed good agreement with those from 3 T, demonstrating feasibility of DENSE MRI at 0.55 T.
Conclusion: Our proposed denoising technique may allow DENSE MRI with improved spatial resolution, efficiency, and accuracy, and enhanced accessibility at 0.55 T.
期刊介绍：
Magnetic Resonance in Medicine (Magn Reson Med) is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications. Reports of original investigations in the areas of mathematics, computing, engineering, physics, biophysics, chemistry, biochemistry, and physiology directly relevant to magnetic resonance will be accepted, as well as methodology-oriented clinical studies.
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