Impact of E-Cigarette Use on Circadian Proteins and Cardiovascular Risk Markers.

IF 2.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Translational Research Pub Date : 2026-03-09 DOI:10.1007/s12265-026-10762-y

Ayman Alzu'bi, Ejlal Abu-El-Rub, Ramada R Khaswaneh, Mohammed Al-Zubaidi, Wissam Almomani, Abdelrahman Alenaizat, Adnan H Ayyash, Anas Alragheb, Anas Alshannag, Enas Ahmad, Mai Elaarag, Raed M Al-Zoubi

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Abstract

The increasing popularity of E-cigarettes among young adults has raised concerns about their health effects, particularly on the circadian system, which regulates critical physiological processes. This study examined how vaping influences circadian proteins and inflammatory markers, comparing these effects to those in cardiovascular disease patients. Blood samples from 254 participants, non-vaping controls (n = 90), regular vapers (n = 86), and cardiovascular patients (n = 78), were analyzed for circadian proteins (Melatonin, BMAL1, PER1, PER2, CRY1, CRY2) and inflammatory/oxidative stress markers (IFN-γ, MDA). Vaping significantly decreased Melatonin, PER1, PER2, CRY1, and CRY2, while BMAL1 remained unchanged. Elevated IFN-γ and MDA levels indicated increased inflammation and oxidative stress in vapers. Vaping induces circadian disruption patterns similar to cardiovascular disease, suggesting a potential mechanism linking e-cigarette use to increased cardiovascular risk.

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电子烟使用对昼夜蛋白和心血管风险标志物的影响。

电子烟在年轻人中越来越受欢迎，引发了人们对其健康影响的担忧，尤其是对调节关键生理过程的昼夜节律系统的影响。这项研究调查了电子烟如何影响昼夜节律蛋白和炎症标志物，并将这些影响与心血管疾病患者的影响进行了比较。研究人员分析了254名参与者、非吸电子烟对照组（n = 90）、常规吸电子烟者（n = 86）和心血管患者（n = 78）的血液样本，以检测昼夜节律蛋白（褪黑激素、BMAL1、PER1、PER2、CRY1、CRY2）和炎症/氧化应激标志物（IFN-γ、MDA）。电子烟显著降低褪黑素、PER1、PER2、CRY1和CRY2，而BMAL1保持不变。IFN-γ和MDA水平升高表明受试者炎症和氧化应激增加。电子烟会导致与心血管疾病类似的昼夜节律紊乱模式，这表明电子烟的使用与心血管风险增加有潜在的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiovascular Translational Research CARDIAC & CARDIOVASCULAR SYSTEMS-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

6.10

自引率

2.90%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research. JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials. JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.