{"title":"Chemistry and bioactivities of erinacines from Hericium fungi","authors":"Yhiya Amen, Ahmed Othman , Kuniyoshi Shimizu","doi":"10.1007/s11418-026-02005-w","DOIUrl":null,"url":null,"abstract":"<div><p>Erinacines are a class of cyathane diterpenoids predominantly biosynthesized in the mycelia of the medicinal mushroom <i>Hericium erinaceus</i>, commonly known as Lion’s Mane or Yamabushitake. Recognized as the main constituents responsible for the neurological effects of <i>Hericium</i> species, erinacines exhibit a range of biological properties, including anti-inflammatory, neurotrophic, neurogenic, antidepressant, and anticancer activities, as well as κ-opioid receptor agonist activity. This review provides a detailed analysis of the pharmacological potential of the twenty-three erinacines reported to date, along with their comprehensive nuclear magnetic resonance (NMR) characterization. This work underscores the promise of erinacines as valuable lead compounds for the development of therapeutic agents.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"80 3","pages":"493 - 512"},"PeriodicalIF":2.6000,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Medicines","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s11418-026-02005-w","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Erinacines are a class of cyathane diterpenoids predominantly biosynthesized in the mycelia of the medicinal mushroom Hericium erinaceus, commonly known as Lion’s Mane or Yamabushitake. Recognized as the main constituents responsible for the neurological effects of Hericium species, erinacines exhibit a range of biological properties, including anti-inflammatory, neurotrophic, neurogenic, antidepressant, and anticancer activities, as well as κ-opioid receptor agonist activity. This review provides a detailed analysis of the pharmacological potential of the twenty-three erinacines reported to date, along with their comprehensive nuclear magnetic resonance (NMR) characterization. This work underscores the promise of erinacines as valuable lead compounds for the development of therapeutic agents.
Graphical abstract
The alternative text for this image may have been generated using AI.
期刊介绍：
The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers:
-chemistry of natural products
-biochemistry of medicinal plants
-pharmacology of natural products and herbs, including Kampo formulas and traditional herbs
-botanical anatomy
-cultivation of medicinal plants.
The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
