Antipsychotic aripiprazole affects the sexual behavior and biochemical parameters of female Wistar rats

IF 3.4 4区医学 Q2 REPRODUCTIVE BIOLOGY

Reproductive toxicology Pub Date : 2026-05-01 Epub Date: 2026-03-07 DOI:10.1016/j.reprotox.2026.109212

Aline Gabrielle Gomes da Silva , Artemia Kelly Holanda Pereira , Ana Beatriz Silva Angelo , Caio César Araújo dos Santos , Renata Gleysiane de Sousa Felix , Maria Joana Nogueira de Moura , Lícia Gabrielle Gomes de Oliveira , Michelly Fernandes de Macedo , Cibele dos Santos Borges

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引用次数: 0

Abstract

Aripiprazole is a drug that modulates both the dopaminergic and serotonergic systems. It is currently widely used in the treatment of schizophrenia and mental disorders due to its stabilizing effect on the dopaminergic system. Studies on psychotropic drugs have demonstrated negative effects on hormonal regulation and sexual behavior as a consequence of their mechanism of action; however, the potential genotoxic effects of aripiprazole have not yet been fully clarified. Given the limited number of studies on the changes that this drug can cause in the reproductive system, the present study aimed to evaluate the impacts of aripiprazole on fertility and female sexual behavior, focusing on metabolic and endocrine-reproductive responses through biochemical and toxicological parameters related to reproduction. For this purpose, adult rats were divided into four experimental groups and subjected to different doses of aripiprazole (0, 0.3, 3.0, and 6.0 mg/kg), diluted in the vehicle (DMSO and saline) by gavage for 21 days. Estrous cyclicity was monitored, and reproductive and biochemical parameters were evaluated at the end of treatment. The results showed that there was no increase in body weight and that the data, in general, did not follow the monotonic dose-response curve. Biochemical changes in creatinine, albumin, and triglycerides were observed, in addition to adverse effects on cyclicity and sexual behavior. Thus, aripiprazole at doses of 0.3 and 6.0 mg/kg in this experimental model may cause toxic effects on the endocrine-reproductive system of fertile rats.

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抗精神病药物阿立哌唑对雌性Wistar大鼠性行为及生化指标的影响

阿立哌唑是一种调节多巴胺能和血清素能系统的药物。由于其对多巴胺能系统的稳定作用，目前广泛应用于精神分裂症和精神障碍的治疗。对精神药物的研究表明，由于其作用机制，对激素调节和性行为有负面影响；然而，阿立哌唑潜在的遗传毒性作用尚未完全阐明。鉴于目前关于阿立哌唑对生殖系统影响的研究有限，本研究旨在通过与生殖相关的生化和毒理学参数，评估阿立哌唑对生育能力和女性性行为的影响，重点关注代谢和内分泌生殖反应。为此，将成年大鼠分为4个实验组，分别给予不同剂量的阿立哌唑（0、0.3、3.0、6.0 mg/kg），用DMSO和生理盐水稀释后灌胃21 d。监测发情周期，并在治疗结束时评估生殖和生化参数。结果表明，体重没有增加，数据总体上不遵循单调的剂量-反应曲线。除了对循环和性行为的不良影响外，还观察到肌酐、白蛋白和甘油三酯的生化变化。由此可见，在本实验模型中，0.3和6.0 mg/kg剂量的阿立哌唑可能对可育大鼠的内分泌生殖系统产生毒性作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive toxicology 生物-毒理学

CiteScore

6.50

自引率

3.00%

发文量

131

审稿时长

45 days

期刊介绍： Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.