Recent advances in greener alternative solvents for reversed-phase liquid chromatography in pharmaceutical analysis

IF 4 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Journal of Chromatography A Pub Date : 2026-05-10 Epub Date: 2026-02-27 DOI:10.1016/j.chroma.2026.466847

Haile Kassahun , Ann Van Schepdael , Erwin Adams

{"title":"Recent advances in greener alternative solvents for reversed-phase liquid chromatography in pharmaceutical analysis","authors":"Haile Kassahun , Ann Van Schepdael , Erwin Adams","doi":"10.1016/j.chroma.2026.466847","DOIUrl":null,"url":null,"abstract":"<div><div>Reversed-phase liquid chromatography (RP-LC) is widely used in pharmaceutical analysis, often relying on traditional organic solvents which present significant environmental and health risks. As a result, the growing demand for sustainable analytical practices has led to the development of eco-friendly solvents for RP-LC. This review discusses recent developments in the application of greener alternative solvents, such as ethanol, glycerol, dimethyl carbonate, cyrene, acetone, propylene carbonate, ionic liquids, propylene glycol, deep eutectic solvents, and surfactants, in pharmaceutical analysis using RP-LC. The review also highlights the potential of these greener solvents to replace conventional ones in the analysis of pharmaceuticals. Overall, green solvents can achieve analytical performance comparable to traditional methods while significantly reducing environmental burden and health risks. The limitations and practical strategies to overcome the challenges are also discussed.</div></div>","PeriodicalId":347,"journal":{"name":"Journal of Chromatography A","volume":"1774 ","pages":"Article 466847"},"PeriodicalIF":4.0000,"publicationDate":"2026-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chromatography A","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0021967326001779","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/27 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}

引用次数: 0

Abstract

Reversed-phase liquid chromatography (RP-LC) is widely used in pharmaceutical analysis, often relying on traditional organic solvents which present significant environmental and health risks. As a result, the growing demand for sustainable analytical practices has led to the development of eco-friendly solvents for RP-LC. This review discusses recent developments in the application of greener alternative solvents, such as ethanol, glycerol, dimethyl carbonate, cyrene, acetone, propylene carbonate, ionic liquids, propylene glycol, deep eutectic solvents, and surfactants, in pharmaceutical analysis using RP-LC. The review also highlights the potential of these greener solvents to replace conventional ones in the analysis of pharmaceuticals. Overall, green solvents can achieve analytical performance comparable to traditional methods while significantly reducing environmental burden and health risks. The limitations and practical strategies to overcome the challenges are also discussed.

查看原文本刊更多论文

药物分析中反相液相色谱绿色替代溶剂的研究进展

反相液相色谱法（RP-LC）在药物分析中应用广泛，通常依赖于传统的有机溶剂，存在重大的环境和健康风险。因此，对可持续分析实践日益增长的需求导致了RP-LC的环保溶剂的发展。本文综述了近年来乙醇、甘油、碳酸二甲酯、癸烯、丙酮、碳酸丙烯、离子液体、丙二醇、深度共晶溶剂和表面活性剂等绿色替代溶剂在RP-LC药物分析中的应用进展。这篇综述还强调了这些绿色溶剂在药物分析中取代传统溶剂的潜力。总体而言，绿色溶剂可以实现与传统方法相当的分析性能，同时显着减少环境负担和健康风险。并讨论了其局限性和克服挑战的实用策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Chromatography A 化学-分析化学

CiteScore

7.90

自引率

14.60%

发文量

742

审稿时长

45 days

期刊介绍： The Journal of Chromatography A provides a forum for the publication of original research and critical reviews on all aspects of fundamental and applied separation science. The scope of the journal includes chromatography and related techniques, electromigration techniques (e.g. electrophoresis, electrochromatography), hyphenated and other multi-dimensional techniques, sample preparation, and detection methods such as mass spectrometry. Contributions consist mainly of research papers dealing with the theory of separation methods, instrumental developments and analytical and preparative applications of general interest.