Determination of low glucose level using smart copper(II)oxide 2D-microelectronic sensor

IF 5.8 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry Pub Date : 2026-05-05 Epub Date: 2026-03-02 DOI:10.1016/j.rechem.2026.103188

Olayemi J. Fakayode , Sisonke Sigonya , Busisiwe P. Mabuea , Dieketseng Tsotetsi , Mokhotjwa S. Dhlamini , Pauline Ncube , Mokgaotsa J. Mochane , Bulelwa Ntsendana , Bakang M. Mothudi

{"title":"Determination of low glucose level using smart copper(II)oxide 2D-microelectronic sensor","authors":"Olayemi J. Fakayode , Sisonke Sigonya , Busisiwe P. Mabuea , Dieketseng Tsotetsi , Mokhotjwa S. Dhlamini , Pauline Ncube , Mokgaotsa J. Mochane , Bulelwa Ntsendana , Bakang M. Mothudi","doi":"10.1016/j.rechem.2026.103188","DOIUrl":null,"url":null,"abstract":"<div><div>Hypoglycemia is an episode associated with very low glucose levels, which can be life-threatening. While research on high glucose levels related to diabetes is common, targeted critical low glucose level detection has received less attention. This study reports copper (II) oxide (CuO) micro-electronic leaflets as a smart sensor for monitoring critical low glucose levels in neutral aqueous solutions. The sensor exhibited a limit of detection (LOD) of about 2.43 × 10<sup>−3</sup> mol/L (2.43 mM, 43.78 mg/dL) in KCl solution and 81.2 × 10<sup>−6</sup> mol/L (81.2 μM, (1.46 mg/dL) in a complex medium containing ammonium phosphate, sodium chloride and sodium acetate (pH 7.12), important values for hypoglycemia, at an applied potential of +0.225 V and −0.05 V vs. Ag/AgCl (3 M KCl) respectively. In addition, a real-life body fluid sample was evaluated through spiking with a recovery of about 99.97%. Overall, the 2D-CuO nano-edge microstructures indicate potential for rapid and reliable glucose sensing in clinical and industrial food environments.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"24 ","pages":"Article 103188"},"PeriodicalIF":5.8000,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Results in Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221171562600161X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/3/2 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Hypoglycemia is an episode associated with very low glucose levels, which can be life-threatening. While research on high glucose levels related to diabetes is common, targeted critical low glucose level detection has received less attention. This study reports copper (II) oxide (CuO) micro-electronic leaflets as a smart sensor for monitoring critical low glucose levels in neutral aqueous solutions. The sensor exhibited a limit of detection (LOD) of about 2.43 × 10⁻³ mol/L (2.43 mM, 43.78 mg/dL) in KCl solution and 81.2 × 10⁻⁶ mol/L (81.2 μM, (1.46 mg/dL) in a complex medium containing ammonium phosphate, sodium chloride and sodium acetate (pH 7.12), important values for hypoglycemia, at an applied potential of +0.225 V and −0.05 V vs. Ag/AgCl (3 M KCl) respectively. In addition, a real-life body fluid sample was evaluated through spiking with a recovery of about 99.97%. Overall, the 2D-CuO nano-edge microstructures indicate potential for rapid and reliable glucose sensing in clinical and industrial food environments.

Abstract Image

查看原文本刊更多论文

智能氧化铜2d微电子传感器测定低血糖水平

低血糖症是一种与血糖水平过低相关的疾病，可能危及生命。虽然研究与糖尿病相关的高血糖水平是常见的，但有针对性的临界低血糖水平检测却很少受到关注。本研究报道了氧化铜（CuO）微电子小叶作为监测中性水溶液中临界低血糖水平的智能传感器。该传感器的检出限（LOD）在KCl溶液中约为2.43 × 10−3 mol/L (2.43 mM, 43.78 mg/dL)，在含有磷酸铵、氯化钠和乙酸钠（pH 7.12）的复杂介质中约为81.2 × 10−6 mol/L (81.2 μM, 1.46 mg/dL)，这是低血糖的重要值，外加电位分别为+0.225 V和- 0.05 V, vs. Ag/AgCl （3 M KCl）。此外，对实际体液样品进行了峰化评价，回收率约为99.97%。总的来说，2D-CuO纳米边缘微结构显示了在临床和工业食品环境中快速可靠的葡萄糖传感的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊