Pharmaceutical pollutant ornidazole sensing at mesoporous spinel cobalt cerium oxide and graphene nanoplatelets modified electrode in environmental water and fish samples

IF 5.2 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal Pub Date : 2026-04-01 Epub Date: 2026-02-13 DOI:10.1016/j.microc.2026.117311

Viswa Muthiah , Venkataraman Dharuman

{"title":"Pharmaceutical pollutant ornidazole sensing at mesoporous spinel cobalt cerium oxide and graphene nanoplatelets modified electrode in environmental water and fish samples","authors":"Viswa Muthiah , Venkataraman Dharuman","doi":"10.1016/j.microc.2026.117311","DOIUrl":null,"url":null,"abstract":"<div><div>Presence of pharmaceutical pollutants greater than the permissible concentration in the environmental water poses significant health problems and affect environmental health underscoring the development of sensitive techniques to monitor. This study synthesized mesoporous spinel cobalt cerium oxide (CoCe2O4) using the simple hydrothermal method and anchored with graphene nanoplatelets through physical adsorption (CoCe2O4/Gr NP). Characterization was done using X-ray diffraction (XRD), Raman spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), high resolution transmission electron microscopy (HR-TEM), field-emission scanning electron microscopy (FE-SEM) and Brunauer-Emmett-Teller (BET). Studies confirmed spherical and mesoporous structure of the composite. The electrochemical study in the presence of [Fe(CN)6]3−/4- reveals the highest redox current with lower ∆Ep (77 mV) for the CoCe2O4/Gr compared to the Co3O4 (∆Ep: 180 mV) and CoCe2O4 (∆Ep: 221 mV) and Gr NP (∆Ep: 83 mV) modified electrodes due to the improved surface area and conductivity. In the presence of ODZ, the sensor showed highest and very sharp reduction peak (ipa: −22.95 μA) at the lowest overpotential −0.574 V with the sensitivity of 0.1924 μA μM−1 cm−2, limit of detection (LOD) of 0.0639 μM, limit of quantification (LOQ) of 0.2128 μM. A linear detection range from 125 nM to 1.674 mM with good reproducibility, renewability and stability was obtained. Practical application was demonstrated using pharmaceutical tablets, environmental water samples (lake, well, and tap water), fish samples, and achieved high recovery rates.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117311"},"PeriodicalIF":5.2000,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchemical Journal","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0026265X26005138","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/13 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Presence of pharmaceutical pollutants greater than the permissible concentration in the environmental water poses significant health problems and affect environmental health underscoring the development of sensitive techniques to monitor. This study synthesized mesoporous spinel cobalt cerium oxide (CoCe₂O₄) using the simple hydrothermal method and anchored with graphene nanoplatelets through physical adsorption (CoCe₂O₄/Gr NP). Characterization was done using X-ray diffraction (XRD), Raman spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), high resolution transmission electron microscopy (HR-TEM), field-emission scanning electron microscopy (FE-SEM) and Brunauer-Emmett-Teller (BET). Studies confirmed spherical and mesoporous structure of the composite. The electrochemical study in the presence of [Fe(CN)₆]^3−/4- reveals the highest redox current with lower ∆E_p (77 mV) for the CoCe₂O₄/Gr compared to the Co₃O₄ (∆E_p: 180 mV) and CoCe₂O₄ (∆E_p: 221 mV) and Gr NP (∆E_p: 83 mV) modified electrodes due to the improved surface area and conductivity. In the presence of ODZ, the sensor showed highest and very sharp reduction peak (i_pa: −22.95 μA) at the lowest overpotential −0.574 V with the sensitivity of 0.1924 μA μM⁻¹ cm⁻², limit of detection (LOD) of 0.0639 μM, limit of quantification (LOQ) of 0.2128 μM. A linear detection range from 125 nM to 1.674 mM with good reproducibility, renewability and stability was obtained. Practical application was demonstrated using pharmaceutical tablets, environmental water samples (lake, well, and tap water), fish samples, and achieved high recovery rates.

Abstract Image

查看原文本刊更多论文

介孔尖晶石钴铈氧化物和石墨烯纳米片修饰电极对环境水和鱼样品中药物污染物奥硝唑的传感

环境水中超过允许浓度的药物污染物构成严重的健康问题，并影响环境健康，强调开发敏感的监测技术。本研究采用简单水热法合成了介孔尖晶石型钴铈氧化物（CoCe2O4），并通过物理吸附（CoCe2O4/Gr NP）将其固定在石墨烯纳米片上。采用x射线衍射（XRD）、拉曼光谱、傅里叶变换红外光谱（FT-IR）、x射线光电子能谱（XPS）、高分辨率透射电子显微镜（HR-TEM）、场发射扫描电子显微镜（FE-SEM）和布鲁诺尔-埃米特-泰勒（BET）进行表征。研究证实了复合材料的球形和介孔结构。在[Fe(CN)6]3−/4-存在下的电化学研究表明，与Co3O4（∆Ep: 180 mV）、CoCe2O4（∆Ep: 221 mV）和Gr NP（∆Ep: 83 mV）修饰电极相比，CoCe2O4/Gr的氧化还原电流最高，∆Ep （77 mV）更低。在ODZ存在下，传感器在过电位最低- 0.574 V处显示出最高且极陡的还原峰（ipa: - 22.95 μA），灵敏度为0.1924 μA μM−1 cm−2，检测限（LOD）为0.0639 μM，定量限（LOQ）为0.2128 μM。在125 nM ~ 1.674 mM范围内线性检测，重现性、可重复性和稳定性好。实际应用表明，该方法可用于药物片剂、环境水样（湖泊、水井和自来水）、鱼类样品，并取得了较高的回收率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Microchemical Journal 化学-分析化学

CiteScore

8.70

自引率

8.30%

发文量

1131

审稿时长

1.9 months

期刊介绍： The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field. Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.