Secondary metabolites from the endophytic fungus Hypoxylon sp. HK-37 derived from Aquilaria sinensis

IF 1.7 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2026-04-01 Epub Date: 2026-02-23 DOI:10.1016/j.phytol.2026.104140

Zheng-Zhuo Ren , Kai-Lei He , Fei Wu , Li Yang , Jing-Zhe Yuan , Ze-Sheng Li , Hao-Fu Dai , Wen-Jian Zuo , Hui-Qin Chen

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Abstract

Two new compounds (1 and 2) and one known compound (3) were isolated from the secondary metabolites of endophytic fungus Hypoxylon sp. HK-37 derived from Aquilaria sinensis. Their structures were unambiguously elucidated as 7-ethyl-3,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one (1), 3-(2,6-dihydroxy-4-methylphenyl)-7-methoxyisobenzofuran-1(3H)-one (2), and 6-hydroxy-8-methoxy-3-methyl-1H-2-benzopyran-1-one (3) through comprehensive spectroscopic analyses (HR-ESI-MS, 1D/2D NMR), electronic circular dichroism (ECD) calculations, and comparison with their literature comparison. In vitro biological evaluations revealed that compounds 2 and 3 exhibited weak acetylcholinesterase (AChE) inhibitory activity, while compound 1 demonstrated weak α-glucosidase inhibitory potential. However, none of the compounds (1-3) displayed anti-inflammatory effects. This study represents a significant advancement in exploring the secondary metabolites from A. sinensis-derived endophytic fungi, substantially expanding the chemical diversity and bioactivity profiles of this microbial resource.

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源自沉香的内生真菌HK-37的次生代谢物

从沉香（Aquilaria sinensis）内生真菌HK-37的次生代谢产物中分离到两个新化合物（1和2）和一个已知化合物(3)。通过综合光谱分析（HR-ESI-MS、1D/2D NMR）、电子圆二色性（ECD）计算，并与文献比较，明确其结构为7-乙基-3,6,8-三羟基-3,4-二氢萘-1(2H)- 1(1)、3-（2,6-二羟基-4-甲基苯基）-7-甲氧基异苯并呋喃-1(3H)- 1(2)和6-羟基-8-甲氧基-3-甲基- 1h -2-苯并吡喃-1- 1(3)。体外生物学评价表明，化合物2和3具有较弱的乙酰胆碱酯酶（AChE）抑制活性，而化合物1具有较弱的α-葡萄糖苷酶抑制活性。然而，没有化合物（1-3）显示抗炎作用。本研究在探索中华沙棘内生真菌次生代谢产物方面取得了重大进展，极大地扩展了这一微生物资源的化学多样性和生物活性谱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.