Anti-inflammatory activity of alkaloids from the leaves of Atalantia buxifolia

IF 1.7 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2026-04-01 Epub Date: 2026-02-23 DOI:10.1016/j.phytol.2026.104138

Qianwei Zhou, Min Xiang, Ziwei Feng, Jiyao Tan, Qiping Weng, Xuan He, Yan-Yan Ma, Deng-Gao Zhao

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Abstract

A chemical study on the leaves of Atalantia buxifolia afforded ten compounds. Among them, two were characterized as new alkaloids, namely a benzoyltyramine designated hortiamide B (1) and an acridone alkaloid named acrignine B (2), while the remaining eight were known analogues (3–10). Extensive spectroscopic techniques were employed to determine their structures, with the absolute configuration of 1 being unambiguously established by single-crystal X-ray diffraction analysis. In an evaluation of anti-inflammatory potential, all compounds were tested for their ability to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. This assay revealed that compounds 1, 9, and 10 possessed notable activity, with IC₅₀ values of 8.5 ± 0.7, 12.7 ± 1.2, and 23.4 ± 2.1 μM, respectively. The present work enriches the phytochemical profile of A. buxifolia and highlights specific isolates as valuable candidates for future development of anti-inflammatory agents.

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柳叶生物碱的抗炎活性

对阿塔兰叶的化学成分进行了研究，发现了10种化合物。其中2种为新生物碱，分别为苯甲酰乙胺，命名为hortiamide B(1)和吖啶酮生物碱，命名为acrignine B(2)，其余8种为已知的类似物（3-10）。采用广泛的光谱技术来确定它们的结构，通过单晶x射线衍射分析明确地确定了1的绝对构型。在抗炎潜力的评估中，所有化合物都被测试了它们抑制脂多糖（LPS）刺激的RAW 264.7巨噬细胞中一氧化氮（NO）产生的能力。结果表明，化合物1、9、10的IC50值分别为8.5 ± 0.7、12.7 ± 1.2和23.4 ± 2.1 μM。本研究丰富了布西兰的植物化学特征，并突出了特定的分离物作为未来抗炎药开发的有价值的候选物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.