ANGPTL3-lowering strategies to address residual cardiovascular risk

IF 50.2 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Nature Reviews Cardiology Pub Date : 2026-03-10 DOI:10.1038/s41569-026-01273-z

Farzahna Mohamed, Frederick J. Raal

引用次数: 0

Abstract

Angiopoietin-related protein 3 (ANGPTL3)-lowering therapies are an LDL receptor-independent strategy for patients who remain at high cardiovascular risk despite conventional treatment, including those with familial hypercholesterolaemia. By reducing both LDL-cholesterol and triglyceride-rich lipoprotein levels in plasma, ANGPTL3 inhibition addresses a broader atherogenic burden and might offer advantages over apolipoprotein C3 inhibition, with the potential to reshape the management of refractory dyslipidaemias.

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降低angptl3的策略解决剩余心血管风险。

血管生成素相关蛋白3 （ANGPTL3）降低疗法是一种不依赖LDL受体的策略，适用于那些尽管接受了常规治疗但仍有心血管疾病高风险的患者，包括家族性高胆固醇血症患者。通过降低血浆中ldl -胆固醇和富含甘油三酯的脂蛋白水平，抑制ANGPTL3可以解决更广泛的动脉粥样硬化负担，并且可能比抑制载脂蛋白C3更有优势，具有重塑难治性血脂异常管理的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Cardiology 医学-心血管系统

CiteScore

53.10

自引率

0.60%

发文量

143

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cardiology aims to be the go-to source for reviews and commentaries in the scientific and clinical communities it serves. Focused on providing authoritative and accessible articles enriched with clear figures and tables, the journal strives to offer unparalleled service to authors, referees, and readers, maximizing the usefulness and impact of each publication. It covers a broad range of content types, including Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives, catering to practising cardiologists and cardiovascular research scientists. Authored by renowned clinicians, academics, and researchers, the content targets readers in the biological and medical sciences, ensuring accessibility across various disciplines. In-depth Reviews offer up-to-date information, while Consensus Statements provide evidence-based recommendations. Perspectives and News & Views present topical discussions and opinions, and the Research Highlights section filters primary research from cardiovascular and general medical journals. As part of the Nature Reviews portfolio, Nature Reviews Cardiology maintains high standards and a wide reach.