Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis.

IF 8.9 2区医学 Q1 Medicine

Dialogues in Clinical Neuroscience Pub Date : 2026-12-01 Epub Date: 2026-03-09 DOI:10.1080/19585969.2026.2636459

Chyi-Huey Bai, Hsien-Yu Fan, Hui-An Lin, Sheng-Feng Lin

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引用次数: 0

Abstract

Background: Cognitive impairment is widely reported in migraineurs. A Mendelian randomisation (MR) approach, similar to a randomised-controlled trial, employs single-nucleotide polymorphisms (SNPs) to investigate causal relationships.

Methods: This study comprised one- and two-sample MR analyses of the Taiwan Biobank. Three strategies were used to obtain causal estimates: (1) a polygenic risk score (PRS) method-several SNPs associated with migraines were constructed as a single instrument variable; (2) a meta-analysis of genome-wide association study (GWAS) statistics for traits of migraines and cognitive impairment in the framework of a one-sample MR; and (3) a two-sample MR analysis with a meta-analysis of GWAS statistics in two distinct datasets (IEU GWAS database and the Taiwan Biobank).

Results: In strategy 1, the PRS constructed by 18 selected SNPs exhibited a causal association with cognitive impairment (β = -2.31, 95% confidence interval [CI]: -4.56 to -0.06). In strategy 2, a one-sample MR showed migraines were causally associated with cognitive impairment (inverse-variance weighted [IVW] estimator β = 2.90; 95% CI: 0.90-4.89). In strategy 3, a two-sample MR validated migraines to be causally associated with cognitive impairment (IVW estimator β = 2.43; 95% CI: 1.08-3.78).

Conclusions: Migraine, a polygenic disorder, is causally associated with cognitive impairment.

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偏头痛与认知障碍的关联：单样本和双样本孟德尔随机化分析。

背景：认知障碍在偏头痛中被广泛报道。孟德尔随机化（MR）方法类似于随机对照试验，采用单核苷酸多态性（snp）来调查因果关系。方法：本研究包括台湾生物库的单样本和双样本磁共振分析。采用三种策略来获得因果估计：(1)多基因风险评分（PRS）方法-将与偏头痛相关的几个snp构建为单个工具变量；(2)在单样本MR的框架下，对偏头痛和认知障碍的全基因组关联研究（GWAS）统计数据进行meta分析；(3)对两个不同数据集（IEU GWAS数据库和台湾生物库）的GWAS统计数据进行双样本MR分析和meta分析。结果：在策略1中，由18个选择的snp构建的PRS与认知障碍表现出因果关系（β = -2.31, 95%可信区间[CI]: -4.56 ~ -0.06）。在策略2中，单样本MR显示偏头痛与认知障碍有因果关系（反方差加权[IVW]估计量β = 2.90; 95% CI: 0.90-4.89）。在策略3中，双样本MR验证偏头痛与认知障碍有因果关系（IVW估计值β = 2.43; 95% CI: 1.08-3.78）。结论：偏头痛是一种多基因疾病，与认知障碍有因果关系。

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来源期刊

Dialogues in Clinical Neuroscience Medicine-Psychiatry and Mental Health

CiteScore

19.30

自引率

1.20%

发文量

期刊介绍： Dialogues in Clinical Neuroscience (DCNS) endeavors to bridge the gap between clinical neuropsychiatry and the neurosciences by offering state-of-the-art information and original insights into pertinent clinical, biological, and therapeutic aspects. As an open access journal, DCNS ensures accessibility to its content for all interested parties. Each issue is curated to include expert reviews, original articles, and brief reports, carefully selected to offer a comprehensive understanding of the evolving landscape in clinical neuroscience. Join us in advancing knowledge and fostering dialogue in this dynamic field.