Ammonia: a metabolic checkpoint for Treg potency.

IF 21.6 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2026-04-01 Epub Date: 2026-03-07 DOI:10.1016/j.trecan.2026.02.002

Ali Valipour Motlagh, Eyad Elkord, Weiwei Dai

引用次数: 0

Abstract

Ammonia acts as a metabolic checkpoint fueling regulatory T cells (Tregs). Gu et al. demonstrate that utilizing argininosuccinate lyase-linked survival buffering and a FOXP3-spermine-PPARγ axis for mitochondrial reinforcement allows Tregs to convert toxic waste into suppressive power, driving tumor immune evasion and immunotherapy resistance.

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氨：Treg效力的代谢检查点。

氨作为代谢检查点为调节性T细胞（Tregs）提供能量。Gu等人证明，利用精氨酸琥珀酸裂解酶相关的生存缓冲和foxp3 -精胺- ppar γ轴进行线粒体强化，可以使Tregs将有毒废物转化为抑制能力，从而驱动肿瘤免疫逃避和免疫治疗抵抗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.