Assessing the impact of air pollution on anemia: a comprehensive review and meta-analysis.

IF 2.1 4区医学 Q2 HEMATOLOGY

Expert Review of Hematology Pub Date : 2026-05-01 Epub Date: 2026-03-13 DOI:10.1080/17474086.2026.2643325

Chi-Thien Dinh, Yueh-Lun Lee, Li-Te Chang, Ta-Yuan Chang, Kian Fan Chung, Kang-Yun Lee, Jer-Hwa Chang, Hsiao-Chi Chuang

{"title":"Assessing the impact of air pollution on anemia: a comprehensive review and meta-analysis.","authors":"Chi-Thien Dinh, Yueh-Lun Lee, Li-Te Chang, Ta-Yuan Chang, Kian Fan Chung, Kang-Yun Lee, Jer-Hwa Chang, Hsiao-Chi Chuang","doi":"10.1080/17474086.2026.2643325","DOIUrl":null,"url":null,"abstract":"Introduction: Air pollution and household fuel use may impair hematologic health through inflammation and oxidative stress. We synthesized evidence on associations of ambient/household air pollution with anemia risk and erythrocyte indices.Methods: We searched PubMed, Embase, and Web of Science (inception-27 September 2025). Two reviewers independently screened and extracted data, and assessed risk of bias using Joanna Briggs Institute checklists. Random-effects meta-analyses pooled risk ratios (RRs) per 10 µg/m3 for particulate matter with aerodynamic diameter ≤10 µm (PM10), ≤2.5 µm (PM2.5), and nitrogen dioxide (NO2), and by household fuel type.Results: Thirty-six studies were included. Each 10 µg/m3 increase in PM2.5 and NO2 was associated with higher anemia risk (RR 1.200, 95% CI 1.041-1.384, I2 98.2%; RR 1.127, 95% CI 1.025-1.241, I2 98.0%). Solid and biomass fuel increased anemia risk (RR 1.143, 95% CI 1.027-1.274, I2 82.9%; RR 1.271, 95% CI 1.050-1.539, I2 91.7%). PM10 was associated with lower hemoglobin (0.074 g/dL, 95% CI -0.124 to -0.023, I2 90.7%). Effects were generally stronger in males and in low- and middle-income countries.Conclusions: Ambient and household air pollution are associated with increased anemia risk and reductions in hemoglobin; high heterogeneity and observational designs limit causal inference.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"529-538"},"PeriodicalIF":2.1000,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Hematology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17474086.2026.2643325","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/3/13 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Air pollution and household fuel use may impair hematologic health through inflammation and oxidative stress. We synthesized evidence on associations of ambient/household air pollution with anemia risk and erythrocyte indices.

Methods: We searched PubMed, Embase, and Web of Science (inception-27 September 2025). Two reviewers independently screened and extracted data, and assessed risk of bias using Joanna Briggs Institute checklists. Random-effects meta-analyses pooled risk ratios (RRs) per 10 µg/m³ for particulate matter with aerodynamic diameter ≤10 µm (PM₁₀), ≤2.5 µm (PM_2.5), and nitrogen dioxide (NO₂), and by household fuel type.

Results: Thirty-six studies were included. Each 10 µg/m³ increase in PM_2.5 and NO₂ was associated with higher anemia risk (RR 1.200, 95% CI 1.041-1.384, I² 98.2%; RR 1.127, 95% CI 1.025-1.241, I² 98.0%). Solid and biomass fuel increased anemia risk (RR 1.143, 95% CI 1.027-1.274, I² 82.9%; RR 1.271, 95% CI 1.050-1.539, I² 91.7%). PM₁₀ was associated with lower hemoglobin (0.074 g/dL, 95% CI -0.124 to -0.023, I² 90.7%). Effects were generally stronger in males and in low- and middle-income countries.

Conclusions: Ambient and household air pollution are associated with increased anemia risk and reductions in hemoglobin; high heterogeneity and observational designs limit causal inference.

查看原文本刊更多论文

评估空气污染对贫血的影响：一项综合综述和荟萃分析。

空气污染和家用燃料的使用可能通过炎症和氧化应激损害血液学健康。我们综合了环境/家庭空气污染与贫血风险和红细胞指数相关的证据。方法：检索PubMed、Embase和Web of Science （inception- 2025年9月27日）。两位审稿人独立筛选和提取数据，并使用乔安娜布里格斯研究所的清单评估偏倚风险。随机效应荟萃分析汇总了空气动力学直径≤10 μ m （PM10）、≤2.5 μ m （PM2.5）和二氧化氮（NO2）以及家用燃料类型的每10 μ g/m3颗粒物的风险比（rr）。结果：纳入36项研究。PM2.5和NO2浓度每增加10µg/m3，贫血风险增加（RR 1.200, 95% CI 1.041 ~ 1.384, I²98.2%;RR 1.127, 95% CI 1.025 ~ 1.241, I²98.0%）。固体燃料和生物质燃料增加贫血风险（RR 1.143, 95% CI 1.027-1.274, I2 82.9%; RR 1.271, 95% CI 1.050-1.539, I2 91.7%）。PM10与较低的血红蛋白相关（0.074 g/dL, 95% CI -0.124 ~ -0.023, i290.7%）。这种影响在男性和中低收入国家普遍更强。结论：环境和家庭空气污染与贫血风险增加和血红蛋白降低有关；高异质性和观察性设计限制了因果推断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Expert Review of Hematology HEMATOLOGY-

CiteScore

4.70

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Advanced molecular research techniques have transformed hematology in recent years. With improved understanding of hematologic diseases, we now have the opportunity to research and evaluate new biological therapies, new drugs and drug combinations, new treatment schedules and novel approaches including stem cell transplantation. We can also expect proteomics, molecular genetics and biomarker research to facilitate new diagnostic approaches and the identification of appropriate therapies. Further advances in our knowledge regarding the formation and function of blood cells and blood-forming tissues should ensue, and it will be a major challenge for hematologists to adopt these new paradigms and develop integrated strategies to define the best possible patient care. Expert Review of Hematology (1747-4086) puts these advances in context and explores how they will translate directly into clinical practice.