Relationship Between Left Ventricular Remodeling Assessed by Strain Echocardiography and Conventional Echocardiography Before and After Cardiac Resynchronization Therapy in Severe Heart Failure Patients.

IF 2.5 Q3 CELL BIOLOGY

Cellular Physiology and Biochemistry Pub Date : 2026-02-07 DOI:10.33594/000000874

Giang Song Tran, Bang Phu Thi Hoang, Si Dung Chu

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引用次数: 0

Abstract

Background/aims: To assess the relationship between left ventricular remodeling as evaluated by strain echocardiography and conventional echocardiography before and after cardiac resynchronization therapy (CRT) in patients with severe heart failure.

Methods: A cross-sectional descriptive study with follow-up comparison before and after CRT. The study included 33 heart failure patients indicated for CRT at the Vietnam National Heart Institute, Bach Mai Hospital from late 2015 to December 2021.

Results: Left ventricular end-systolic volume and end-diastolic volume significantly decreased after three months of follow-up (p < 0.001) and showed a strong inverse correlation with QRS recovery (r = 0.65). A positive correlation was observed between changes in left atrial volume index (LAVI) and 4B strain (r = 0.96, p < 0.05). After three months of CRT implantation, positive correlations were observed between isovolumic relaxation time (IVRT) and left atrial volume index (LAVI), and between left atrial volume and E/e' obtained from tissue Doppler imaging (r = 0.53, p < 0.05). No correlation was found between E/e' and total EF, between 2B strain and total EF, or between 2B strain and LAVI.

Conclusion: Strain echocardiography represents an important tool for diagnosing, assessing risk factors, and monitoring heart failure. After three months of CRT implantation, significant improvement in left ventricular volume and ejection fraction was observed, indicating improved treatment effectiveness.

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重型心力衰竭患者心脏再同步化治疗前后应变超声心动图与常规超声心动图评价左心室重构的关系。

背景/目的：评价重型心力衰竭患者心脏再同步化治疗（CRT）前后应变超声心动图与常规超声心动图评价的左心室重构的关系。方法：采用横断面描述性研究，并对CRT前后进行随访比较。该研究包括2015年底至2021年12月在越南巴赫迈医院国立心脏研究所接受CRT治疗的33例心力衰竭患者。结果：随访3个月后，左室收缩末容积和舒张末容积显著降低（p < 0.001），与QRS恢复呈强负相关（r = 0.65）。左房容积指数（LAVI）与4B菌株变化呈正相关（r = 0.96, p < 0.05）。CRT植入3个月后，等容松弛时间（IVRT）与左房容积指数（LAVI）、左房容积与组织多普勒成像E/ E′呈正相关（r = 0.53, p < 0.05）。E/ E′与总EF、2B菌株与总EF、2B菌株与LAVI均无相关性。结论：应变超声心动图是诊断、评估心衰危险因素和监测心衰的重要工具。CRT植入3个月后，观察到左室容积和射血分数明显改善，表明治疗效果提高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular Physiology and Biochemistry 生物-生理学

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Cellular Physiology and Biochemistry is a multidisciplinary scientific forum dedicated to advancing the frontiers of basic cellular research. It addresses scientists from both the physiological and biochemical disciplines as well as related fields such as genetics, molecular biology, pathophysiology, pathobiochemistry and cellular toxicology & pharmacology. Original papers and reviews on the mechanisms of intracellular transmission, cellular metabolism, cell growth, differentiation and death, ion channels and carriers, and the maintenance, regulation and disturbances of cell volume are presented. Appearing monthly under peer review, Cellular Physiology and Biochemistry takes an active role in the concerted international effort to unravel the mechanisms of cellular function.